Korean J Pathol.
2002 Oct;36(5):338-340.
Partial Trisomy 13 (Patau Syndrome): An Autopsy Report
- Affiliations
-
- 1Department of Pathology, College of Medicine, Hallym University, Chuncheon, Korea. kcchoi@hallym.ac.kr
- 2Department of Obstetrics and Gynecology, College of Medicine, Hallym University, Chuncheon, Korea.
- 3Department of Obstetrics and Gynecology, Pohang Christian Hospital, Pohang, Korea.
Abstract
- Trisomy 13 (Patau syndrome) is rare and usually fatal if contracted within the first six months of life. We report a case of a male fetus with the typical features of Patau syndrome. He was terminated in a 27-year-old mother at the gestational age of 32+4 weeks. In chromsomal analysis by GTG banding technique, the karyotype of the fetus was 46,XY,rec(13) dup(13q)inv(13)(p13q21.3)(=partial trisomy 13q); and his mother's karyotype was 46,XX, inv(13)(p13q21.3)(=pericentric inversion). His father had normal karyotype, 46,XY. Ultrasonography showed fluid-nature content, which was occupying the entire intracranium, but preserving the brain stem and cerebellum. Postmortem examination disclosed holoprosencephaly, hydrocephalus, a single nostril, bilateral anophthalmia, ventricular septal defect, and a single umbilical artery.
