Korean J Pathol.
2003 Oct;37(5):369-372.
Silica Granuloma after Intermittent Intramuscular Injections: A Case Report
- Affiliations
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- 1Department of Pathology, Dongguk University, College of Medicine, Kyongju, Korea. pathjrk@dumc.or.kr
- 2Department of Orthopaedic Surgery, Dongguk University, College of Medicine, Kyongju, Korea.
Abstract
- Most silica-contaminated wounds of the skin heal without complications. Cutaneous silica granuloma is a poorly understood, uncommon condition resembling a sarcoidosis. We report a case of silica granuloma after intermittent intramuscular injections. A 70-year-old man presented a painless mass in his right buttock for 2 weeks. He had received intermittent intramuscular injections of antihistamine drugs due to chronic dermatitis for 30 years. The histolopathological findings showed numerous hyalinized collagenous nodules with concentric layers, and an ill-defined chronic granulomatous inflammation containing foreign material. A polarized light microscopic examination revealed birefrigent particles. The presence of silica components was confirmed by scanning electron microscopy and energy dispersive X-ray microanalysis.
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