Korean J Pediatr Gastroenterol Nutr.  2000 Mar;3(1):63-67.

Diagnostic Utility of Tc-99m DISIDA Hepatobiliary Scintigraphy in the Diagnosis of Biliary Atresia

• Lee BS
• Choi BH
• Kim KM
• Kum JS
• Moon DH

Abstract

PURPOSE: Biliary atresia, one of the major causes of neonatal cholestais, is an idiopathic, serious disorder, affecting the newborn that results in complete obstruction of biliary tract. Successful reestablishment of bile flow is dependent on early surgical intervention, early diagnosis is imperative. The authors evaluate the utility of Tc-99m-labeled diisoprpyliminodiacetic acid (DISIDA) hepatobiliary scintigraphy in the diagnosis of biliary atresia.
METHODS
From January, 1995 to August, 1999, total 60 patients with neonatal cholestasis underwent Tc-99m DISIDA hepatobiliary scintigraphy at Asan Medical Center.
RESULTS
The undelying causes of neonatal cholestasis were biliary atresia in 14, neonatal hepatitis in 33, intrahepatic bile duct paucity in 9, and total parenteral nutrition induced cholestasis in 4. All patient with biliary atresia were interpreted correctely in DISIDA hepatobiliary scintigraphy, showing 100% sensitivity. Of the 46 patients with neonatal hepatitis and other causes, 37 patients had intestinal radioactivity showing 80% specificity.
CONCLUSION
Visualization of DISIDA in the intestinal tract indicates patency of the biliary ducts and excludes the diagnosis of biliary atresia. But the absence of intestinal excretion on the DISIDA hepatobiliary scintigraphy dose not necessarily indicate biliary atresia.

Keyword

Biliary atresia; Neonatal cholestasis; Tc-99m DISIDA hepatobiliary scintigraphy

MeSH Terms

Bile
Bile Ducts, Intrahepatic
Biliary Atresia*
Biliary Tract
Cholestasis
Chungcheongnam-do
Diagnosis*
Early Intervention (Education)
Hepatitis
Humans
Infant, Newborn
Parenteral Nutrition, Total
Radioactivity
Radionuclide Imaging*
Sensitivity and Specificity