Korean J Obstet Gynecol.  2012 Dec;55(12):1039-1042. 10.5468/KJOG.2012.55.12.1039.

A case of resistant ovary syndrome

• Kim SS
• Jo IH
• Jeong EJ
• Seo YJ
• Byun JM
• Jeong DH
• Sung MS
• Kim KT
• Lee KB

• KMID: 2274222
• DOI: http://doi.org/10.5468/KJOG.2012.55.12.1039

Abstract

A 21-year-old female with primary amenorrhea, sexual infantilism, and phenotypic female visited our Obstetrics and Gynecology Clinics. The patient showed elevated follicle stimulating hormone and luteinizing hormone, decreased estradiol, normal thyroid-stimulating hormone and prolactin level that means hypergonadotropic hypogonadism with normal 46, XX karyotype. Under diagnostic laparoscopy, both ovaries were intact morphology, small but anatomically normal uterus and vagina. Ovarian biopsy was taken and reported abundant primodial follicles and sporadic preantral follicles. We concluded that final diagnosis is resistant ovarian syndrome.

Keyword

Resistant ovary syndrome; Primary amenorrhea; Primary ovarian insufficiency; Hypergonadotropic hypogonadism

MeSH Terms

Amenorrhea
Biopsy
Estradiol
Female
Follicle Stimulating Hormone
Gynecology
Humans
Hypogonadism
Karyotype
Laparoscopy
Luteinizing Hormone
Obstetrics
Ovary
Primary Ovarian Insufficiency
Prolactin
Sexual Infantilism
Thyrotropin
Uterus
Vagina
Estradiol
Follicle Stimulating Hormone
Luteinizing Hormone
Prolactin
Thyrotropin

Figure

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  Fig. 1 Laparoscopic findings: normal ovary, streak uterus, intact uterine arteries and round ligament.

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  Fig. 2 Ovarian hystologic finding: abundant primordial follicles and sporadic preantral follicles (H&E, ×100).

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