Korean J Obstet Gynecol.  2012 Dec;55(12):1026-1030. 10.5468/KJOG.2012.55.12.1026.

A case of multiple primary malignancies following radiotherapy for adenosquamous cell carcinoma of the cervix

Affiliations
  • 1Department of Obstetrics and Gynecology, Dankook University College of Medicine, Cheonan, Korea. soo8541@hanmail.net

Abstract

Given the extended survival of patients diagnosed with cervical cancer, a large number of women are treated with radiotherapy. A second primary cancer has currently become one of the most important radiation-induced injuries as the number of cancer patients who are cured is increasing by virtue of recent advancements in therapeutic radiology. A 56-year-old woman developed two pelvic malignancies 14 years after undergoing surgery and radiotherapy for adenosquamous cell carcinoma of the cervix. Previous exposure to radiotherapy is associated with certain malignancies, and review of the literature indicates that there is strong evidence to support such an association with bladder and ovarian cancer. This is the first reported case of second multiple primary malignancies (ovarian cancer and bladder cancer) after radiation therapy for adenosquamous cell carcinoma of the cervix.

Keyword

Radiotherapy; Uterine cervical cancer; Ovarian cancer; Urinary bladder cancer

MeSH Terms

Cervix Uteri
Female
Humans
Neoplasms, Second Primary
Ovarian Neoplasms
Radiation Oncology
Urinary Bladder
Urinary Bladder Neoplasms
Uterine Cervical Neoplasms
Virtues

Figure

  • Fig. 1 Low-magnified view of an adenosquamous carcinoma show a glandular differentiation with multilayered growth. It also reveals a squamous differentiation in a big tumor cell cluster with sheet-like and focally whorling apperances (H&E, ×100).

  • Fig. 2 The axial view of post-contrast computed tomography showed a pelvic mass with a huge ascites. The margin is irregular and cystic-solid mass in pelvic cavity (arrow).

  • Fig. 3 Histologically, the tumor of ovary consists of polygonal pleomorphic cells arranged in solid sheets or lacy pattern. Psammoma bodies are also present (H&E, ×100).

  • Fig. 4 Right lateral wall of bladder: consistent with papillary transitional cell carcinoma, low-grade (H&E, ×100).

  • Fig. 5 The tumor cells are positive for CK7 (Immunohistochemistry, ×200).


Reference

1. Takeda T, Sagae S, Koizumi M, Terasawa K, Ishioka S, Takashima S, et al. Multiple primary malignancies in patients with gynecologic cancer. Int J Gynecol Cancer. 1995. 5:34–39.
2. Benedet JL, Odicino F, Maisonneuve P, Beller U, Creasman WT, Heintz AP, et al. Carcinoma of the cervix uteri. Int J Gynaecol Obstet. 2003. 83:Suppl 1. 41–78.
3. Barillot I, Horiot JC, Pigneux J, Schraub S, Pourquier H, Daly N, et al. Carcinoma of the intact uterine cervix treated with radiotherapy alone: a French cooperative study: update and multivariate analysis of prognostics factors. Int J Radiat Oncol Biol Phys. 1997. 38:969–978.
4. Billroth T. Die allgemeine chirurgische pathologie und therapie. 1889. Berlin: G. Reimer.
5. Werthamer S, Jabush M, Schulman J. Multiple primary malignancies. JAMA. 1961. 175:558–562.
6. Matlock DL, Salem FA, Charles EH, Savage EW. Synchronous multiple primary neoplasms of the upper female genital tract. Gynecol Oncol. 1982. 13:271–277.
7. Moertel CG, Dockerty MB, Baggenstoss AH. Multiple primary malignant neoplasms. II. Tumors of different tissues or organs. Cancer. 1961. 14:231–237.
8. Stovall M, Smith SA, Rosenstein M. Tissue doses from radiotherapy of cancer of the uterine cervix. Med Phys. 1989. 16:726–733.
9. Boice JD Jr, Engholm G, Kleinerman RA, Blettner M, Stovall M, Lisco H, et al. Radiation dose and second cancer risk in patients treated for cancer of the cervix. Radiat Res. 1988. 116:3–55.
10. Boice JD Jr, Day NE, Andersen A, Brinton LA, Brown R, Choi NW, et al. Second cancers following radiation treatment for cervical cancer. An international collaboration among cancer registries. J Natl Cancer Inst. 1985. 74:955–975.
11. Arai T, Nakano T, Fukuhisa K, Kasamatsu T, Tsunematsu R, Masubuchi K, et al. Second cancer after radiation therapy for cancer of the uterine cervix. Cancer. 1991. 67:398–405.
12. Kleinerman RA, Boice JD Jr, Storm HH, Sparen P, Andersen A, Pukkala E, et al. Second primary cancer after treatment for cervical cancer. An international cancer registries study. Cancer. 1995. 76:442–452.
13. Ohno T, Kato S, Sato S, Fukuhisa K, Nakano T, Tsujii H, et al. Long-term survival and risk of second cancers after radiotherapy for cervical cancer. Int J Radiat Oncol Biol Phys. 2007. 69:740–745.
Full Text Links
  • KJOG
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr