Korean J Obstet Gynecol.  2012 Dec;55(12):1026-1030. 10.5468/KJOG.2012.55.12.1026.

A case of multiple primary malignancies following radiotherapy for adenosquamous cell carcinoma of the cervix

• Park JW
• Park YK
• Kim JS

• KMID: 2274219
• DOI: http://doi.org/10.5468/KJOG.2012.55.12.1026

Abstract

Given the extended survival of patients diagnosed with cervical cancer, a large number of women are treated with radiotherapy. A second primary cancer has currently become one of the most important radiation-induced injuries as the number of cancer patients who are cured is increasing by virtue of recent advancements in therapeutic radiology. A 56-year-old woman developed two pelvic malignancies 14 years after undergoing surgery and radiotherapy for adenosquamous cell carcinoma of the cervix. Previous exposure to radiotherapy is associated with certain malignancies, and review of the literature indicates that there is strong evidence to support such an association with bladder and ovarian cancer. This is the first reported case of second multiple primary malignancies (ovarian cancer and bladder cancer) after radiation therapy for adenosquamous cell carcinoma of the cervix.

Keyword

Radiotherapy; Uterine cervical cancer; Ovarian cancer; Urinary bladder cancer

MeSH Terms

Cervix Uteri
Female
Humans
Neoplasms, Second Primary
Ovarian Neoplasms
Radiation Oncology
Urinary Bladder
Urinary Bladder Neoplasms
Uterine Cervical Neoplasms
Virtues

Figure

• 

  Fig. 1 Low-magnified view of an adenosquamous carcinoma show a glandular differentiation with multilayered growth. It also reveals a squamous differentiation in a big tumor cell cluster with sheet-like and focally whorling apperances (H&E, ×100).

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  Fig. 2 The axial view of post-contrast computed tomography showed a pelvic mass with a huge ascites. The margin is irregular and cystic-solid mass in pelvic cavity (arrow).

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  Fig. 3 Histologically, the tumor of ovary consists of polygonal pleomorphic cells arranged in solid sheets or lacy pattern. Psammoma bodies are also present (H&E, ×100).

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  Fig. 4 Right lateral wall of bladder: consistent with papillary transitional cell carcinoma, low-grade (H&E, ×100).

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  Fig. 5 The tumor cells are positive for CK7 (Immunohistochemistry, ×200).

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