Korean J Obstet Gynecol.  2012 Nov;55(11):859-864. 10.5468/KJOG.2012.55.11.859.

Primary malignant lymphoma of the endometrium with lumbar spine involvement

• Kang GE
• Jin SA
• Boo HY
• Pyo JY
• Oh Y
• Kim SR

• KMID: 2274157
• DOI: http://doi.org/10.5468/KJOG.2012.55.11.859

Abstract

Primary malignant lymphomas in the female genital tract are rare, but when it occurs, the cervix or the ovary are more common site than the uterine corpus. Most common symptoms are abnormal vaginal bleeding but sometimes it is symptom free. Due to rarity of primary malignant lymphoma, the standard treatments are not yet established, but rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy after the surgery is general executed. We present a case of primary malignant lymphoma originating from endometrium with spine involvement.

Keyword

Lymphoma; Endometrium; Uterus

MeSH Terms

Antibodies, Monoclonal, Murine-Derived
Cervix Uteri
Cyclophosphamide
Doxorubicin
Endometrium
Female
Humans
Lymphoma
Ovary
Prednisone
Spine
Uterine Hemorrhage
Uterus
Vincristine
Rituximab
Antibodies, Monoclonal, Murine-Derived
Cyclophosphamide
Doxorubicin
Prednisone
Vincristine

Figure

• 

  Fig. 1 Positron emission tomography image; Hypermetabolic huge mass in the pelvic cavity, suggesting malignancy (arrow).

• 

  Fig. 2 Gross findings of oval shaped, enlarged uterine body mass with nodular growth (A) involving entire endomyometirial wall with fish flesh, gray white mass in cut section (B).

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  Fig. 3 Microscopic features of uterine mass. (A) Atypical lymphoid cells diffusely infiltrated in endomyometrium (H&E, ×12.5). (B) The tumor cells have moderate to large nuclei with prominent nucleoli and scanty cytoplasm (H&E, ×400). On immunohistochemical staining, the tumor cells positive for CD79a (C, immunostain, ×400) and Bcl-2 (D, immunostain, ×400).

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