Korean J Obstet Gynecol.  2012 Sep;55(9):678-682. 10.5468/KJOG.2012.55.9.678.

A case of mullerian adenosarcoma of the uterus

• Mo AJ
• Sung JE
• Kyung MS
• Cho Y
• Ro ES
• Choi KC

• KMID: 2274143
• DOI: http://doi.org/10.5468/KJOG.2012.55.9.678

Abstract

Mullerian adenosarcoma which is characterized by admixture of benign-appearing neoplastic glands and sarcomatous stroma, is an uncommon variant of malignant mixed mullerian tumor (MMMT). Classic treatment for this rare tumor is hysterectomy with bilateral salpingo-oophorectomy. Its prognosis is relatively poor, but better than MMMT. The efficacy of adjuvant postoperative radiotherapy and chemotherapy is debatable and appears not to be promising. We report a 62-year-old female with mullerian adenosarcoma diagnosed after hysterectomy with bilateral salpingo-oophorectomy, which had shown unique ultrasonographic feature like hydatidiform mole and had been diagnosed as fibroadenoma in endometrial curettage, with brief review of literatures.

Keyword

Mullerian adenosarcoma; Malignant mixed mullerian tumor; Uterine sarcoma

MeSH Terms

Adenosarcoma
Curettage
Female
Fibroadenoma
Humans
Hydatidiform Mole
Hysterectomy
Middle Aged
Pregnancy
Prognosis
Uterine Neoplasms
Uterus
Adenosarcoma
Uterine Neoplasms

Figure

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  Fig. 1 A mixed echogenic mass of 6.3 × 4.4 cm which is mimic to Hydatidiform mole in transvaginal ultrasonogram.

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  Fig. 2 A polypoid lesion in the uterine cavity, measuring 6 × 5 cm. The cut surface of the lesion was multilobular and cystic.

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  Fig. 3 Histopathological findings of endometrial curettage specimen (H&E, ×100). Fibrous and myxoid stroma surrounding endometrial gland, which is compatible with fibroadenoma.

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  Fig. 4 Histopathological findings of hysterectomy specimen (H&E, ×100). The surface of this tumor has a leaf-like appearance with hypercellular stroma.

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  Fig. 5 Histopathological findings of hysterectomy specimen (H&E, ×400). Cuffing of hypercellular stroma surrounding compressed slit-like glands is seen. Also mitotic figure of stromal cells can be observed (arrow).

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