Obstet Gynecol Sci.  2013 Jul;56(4):269-272.

Synchronous occurrence of primary malignant mixed mullerian tumor in ovary and uterus

Affiliations
  • 1Department of Obstetrics and Gynecology, Kosin University College of Medicine, Busan, Korea. hykyale@yahoo.com
  • 2Department of Obstetrics and Gynecology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
  • 3Department of Obstetrics and Gynecology, Gyeongsang National University School of Medicine, Jinju, Korea.
  • 4Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Korea.

Abstract

Malignant mixed mullerian tumor (MMMT) arising from female internal genitalia is rare with the uterine corpus being the most prevalently affected site. It is even more rare when it occurs on both uterus and ovary at the same time. We describe a case of synchronized occurrence of MMMT on ovary and uterine adenosarcoma with review of literature.

Keyword

Malignant mixed mullerian tumor; Ovary; Uterus

MeSH Terms

Adenosarcoma
Female
Genitalia
Humans
Ovary
Uterine Neoplasms
Uterus
Adenosarcoma
Uterine Neoplasms

Figure

  • Fig. 1 Computed tomography showing a huge sized mass in uterine cavity. And 5.5-cm sized cystic and solid mass in right adnexa (white arrows).

  • Fig. 2 Gross and microscopic findings. (A) Gross findings after surgery: 8×5-cm sized polypoid mass in uterine cavity. (B) The uterine mass shows mainly diffuse sheets of anaplastic sarcomatous components with scattered benign looking glandular components (H&E, ×200). (C) The ovarian mass shows diffuse sheets of mixed adenocarcinoma and anaplastic sarcomatous component (H&E, ×200).


Reference

1. Cantrell LA, Van Le L. Carcinosarcoma of the ovary a review. Obstet Gynecol Surv. 2009; 64:673–680.
2. Clement PB, Scully RE. Mullerian adenosarcoma of the uterus: a clinicopathologic analysis of ten cases of a distinctive type of mullerian mixed tumor. Cancer. 1974; 34:1138–1149.
3. Clement PB, Scully RE. Mullerian adenosarcoma of the uterus: a clinicopathologic analysis of 100 cases with a review of the literature. Hum Pathol. 1990; 21:363–381.
4. Zaino R, Whitney C, Brady MF, DeGeest K, Burger RA, Buller RE. Simultaneously detected endometrial and ovarian carcinomas: a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol. 2001; 83:355–362.
5. Ulbright TM, Roth LM. Metastatic and independent cancers of the endometrium and ovary: a clinicopathologic study of 34 cases. Hum Pathol. 1985; 16:28–34.
6. Arend R, Bagaria M, Lewin SN, Sun X, Deutsch I, Burke WM, et al. Long-term outcome and natural history of uterine adenosarcomas. Gynecol Oncol. 2010; 119:305–308.
7. Brown E, Stewart M, Rye T, Al-Nafussi A, Williams AR, Bradburn M, et al. Carcinosarcoma of the ovary: 19 years of prospective data from a single center. Cancer. 2004; 100:2148–2153.
8. Silverman JF, Gardner J, Larkin EW, Finley JL, Norris HT. Ascitic fluid cytology in a case of metastatic malignant mixed mesodermal tumor of the ovary. Acta Cytol. 1986; 30:173–176.
9. Zaloudek CJ, Norris HJ. Adenofibroma and adenosarcoma of the uterus: a clinicopathologic study of 35 cases. Cancer. 1981; 48:354–366.
10. Sood AK, Sorosky JI, Gelder MS, Buller RE, Anderson B, Wilkinson EJ, et al. Primary ovarian sarcoma: analysis of prognostic variables and the role of surgical cytoreduction. Cancer. 1998; 82:1731–1737.
11. Duska LR, Garrett A, Eltabbakh GH, Oliva E, Penson R, Fuller AF. Paclitaxel and platinum chemotherapy for malignant mixed mullerian tumors of the ovary. Gynecol Oncol. 2002; 85:459–463.
12. Silasi DA, Illuzzi JL, Kelly MG, Rutherford TJ, Mor G, Azodi M, et al. Carcinosarcoma of the ovary. Int J Gynecol Cancer. 2008; 18:22–29.
13. Shi Y, Liu Z, Peng Z, Liu H, Yang K, Yao X. The diagnosis and treatment of Mullerian adenosarcoma of the uterus. Aust N Z J Obstet Gynaecol. 2008; 48:596–600.
14. Tate Thigpen J, Blessing JA, DeGeest K, Look KY, Homesley HD. Gynecologic Oncology Group. Cisplatin as initial chemotherapy in ovarian carcinosarcomas: a Gynecologic Oncology Group study. Gynecol Oncol. 2004; 93:336–339.
15. Sutton GP, Blessing JA, Homesley HD, Malfetano JH. A phase II trial of ifosfamide and mesna in patients with advanced or recurrent mixed mesodermal tumors of the ovary previously treated with platinum-based chemotherapy: a Gynecologic Oncology Group study. Gynecol Oncol. 1994; 53:24.
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