Korean J Obstet Gynecol.  2012 Mar;55(3):143-147. 10.5468/KJOG.2012.55.3.143.

Pharmacotherapy for premenstrual dysphoric disorder: A meta-analysis of phase 3 trials

Affiliations
  • 1Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea. tkim@kumc.or.kr

Abstract

Premenstrual dysphoric disorder (PMDD) is a common condition that temporarily, but repetitively affects patient's global function. Patients and physicians alike are often uncertain whether prescription medication for PMDD is sufficiently effective. The primary objective of this analysis is signal detection in efficacy of pharmacological treatments in PMDD. Secondary objective is to review which symptoms are likely to respond to which medications. The review included otherwise healthy women with clinician confirmed diagnosis of PMDD who participated in phase 3 clinical trials for the treatment of PMDD. Twelve pair-wise comparisons of drug and placebo for 2,420 patients with PMDD were performed. Oral contraceptives and selective serotonin receptor inhibitor were effective in alleviating symptoms of PMDD compared to placebo. Both Intermittent and continuous administration were more effective than placebo. This meta-analysis provides a signal that pharmacological treatment of PMDD is effective.

Keyword

Premenstrual syndrome; Drug therapy; Meta-analysis; Clinical trial, phase 3

MeSH Terms

Contraceptives, Oral
Female
Humans
Premenstrual Syndrome
Prescriptions
Serotonin
Contraceptives, Oral
Serotonin

Figure

  • Fig. 1 Drospirenone (DR)/ethinyl-estradiol (EE). SD, standard deviation; CI, confidence interval. aStudy stage 1; bStudy stage 2; cParoxetine controlled release 12.5 mg (otherwise 25 mg). Heterogeneity: Chiz = 1069.63, df = 11 (P <0.00001); Iz = 99%. Test for overall effect: Z = 151.80 (P <0.00001).


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