Korean J Obstet Gynecol.  2011 Sep;54(9):553-556. 10.5468/KJOG.2011.54.9.553.

A case of successful pregnancy by intrauterine insemination following isthmic dilatation due to isthmic stenosis after laparoscopic radical trachelectomy

Affiliations
  • 1Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. chnkim@amc.seoul.kr

Abstract

Uterine cervical cancer is one of the most common malignant disease in women. For young patients with early stage cervical cancer who want to preserve their fertility, radical trachelectomy is a promising fertility-sparing treatment in well-selected group of patients. However, isthmic stenosis is reported to occur in 15% of patients who received radical trachelectomy. Isthmic stenosis is one of causes of infertility following radical trachelectomy. In addition patients who underwent radical trachelectomy are at high risk of obstetric complications including preterm labor, premature rupture of membrane and preterm delivery. Herein we report a case of successful pregnancy and childbirth by intrauterine insemination following isthmic dilatation due to isthmic stenosis after laparoscopic trachelectomy with a brief review of the literature.

Keyword

Cervical cancer; Laparoscopic radical trachelectomy; Isthmic stenosis; Isthmic dilatation

MeSH Terms

Constriction, Pathologic
Dilatation
Female
Fertility
Humans
Infertility
Insemination
Membranes
Obstetric Labor, Premature
Parturition
Pregnancy
Rupture
Uterine Cervical Neoplasms

Figure

  • Fig. 1 Cervix specimen after radical trachelectomy.

  • Fig. 2 Diagram of isthmic opening location after radical trachelectomy.

  • Fig. 3 Catheter which was used for isthmic dilatation.


Reference

1. Arbyn M, Autier P, Ferlay J. Burden of cervical cancer in the 27 member states of the European Union: estimates for 2004. Ann Oncol. 2007. 18:1423–1425.
2. Rob L, Skapa P, Robova H. Fertility-sparing surgery in patients with cervical cancer. Lancet Oncol. 2011. 12:192–200.
3. Farthing A. Conserving fertility in the management of gynaecological cancers. BJOG. 2006. 113:129–134.
4. Smith HO, Tiffany MF, Qualls CR, Key CR. The rising incidence of adenocarcinoma relative to squamous cell carcinoma of the uterine cervix in the United States: a 24-year population-based study. Gynecol Oncol. 2000. 78:97–105.
5. D'Argent D, Brun JL, Roy M, Remi I. Pregnancies following radical trachelectomy for invasive cervical cancer. Gynecol Oncol. 1994. 52:105.
6. Shepherd JH, Mould T, Oram DH. Radical trachelectomy in early stage carcinoma of the cervix: outcome as judged by recurrence and fertility rates. BJOG. 2001. 108:882–885.
7. Plante M, Renaud MC, Hoskins IA, Roy M. Vaginal radical trachelectomy: a valuable fertility-preserving option in the management of early-stage cervical cancer. A series of 50 pregnancies and review of the literature. Gynecol Oncol. 2005. 98:3–10.
8. Shepherd JH, Spencer C, Herod J, Ind TE. Radical vaginal trachelectomy as a fertility-sparing procedure in women with early-stage cervical cancer-cumulative pregnancy rate in a series of 123 women. BJOG. 2006. 113:719–724.
9. Sonoda Y, Chi DS, Carter J, Barakat RR, Abu-Rustum NR. Initial experience with Dargent's operation: the radical vaginal trachelectomy. Gynecol Oncol. 2008. 108:214–219.
10. Plante M, Gregoire J, Renaud MC, Roy M. The vaginal radical trachelectomy: an update of a series of 125 cases and 106 pregnancies. Gynecol Oncol. 2011. 121:290–297.
11. Carter J, Sonoda Y, Chi DS, Raviv L, Abu-Rustum NR. Radical trachelectomy for cervical cancer: postoperative physical and emotional adjustment concerns. Gynecol Oncol. 2008. 111:151–157.
12. Pareja F R, Ramirez PT, Borrero F M, Angel C G. Abdominal radical trachelectomy for invasive cervical cancer: a case series and literature review. Gynecol Oncol. 2008. 111:555–560.
13. Nishio H, Fujii T, Kameyama K, Susumu N, Nakamura M, Iwata T, et al. Abdominal radical trachelectomy as a fertility-sparing procedure in women with early-stage cervical cancer in a series of 61 women. Gynecol Oncol. 2009. 115:51–55.
14. Kim JW, Kim YH, Choi HS, Kim CH, Cho HY, Cho MK, et al. Successful full-term delivery after abdominal radical trachelectomy and concurrent cervicoisthmic cerclage for early stage cervical cancer: two cases. Korean J Obstet Gynecol. 2009. 52:1159–1163.
15. Yoon G, Choi SJ, Roh CR, Choi DS, Kim JH, Bae DS. Successful twin pregnancy by assisted reproductive technology after laparoscopic-assisted radical vaginal trachelectomy. J Womens Med. 2010. 3:23–25.
Full Text Links
  • KJOG
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr