Korean J Obstet Gynecol.  2011 Aug;54(8):459-463. 10.5468/KJOG.2011.54.8.459.

Placental mesenchymal dysplasia associated with severe preeclampsia: A case report

• Na ED
• Lee KJ
• Kim MJ
• Yi HJ
• Kim JY

• KMID: 2274067
• DOI: http://doi.org/10.5468/KJOG.2011.54.8.459

Abstract

Placental mesenchymal dysplasia (PMD) is a relatively recently recognized, rare placental vascular anomaly characterized by placentomegaly and grapelike vesicles that may coexist with a normal fetus. Ultrasonography performed at 16 weeks of gestation revealed multiple cysts in the placenta along with a morphologically normal fetus. At 24 weeks of gestational age, severe preeclampsia symptoms were seen. And sonographically intrauterine growth restriction (IUGR) and oligohydroamnios were noted. Based on the diagnosis of severe preeclampsia, termination of pregnancy was done. After termination, histopathologic examination of the placenta showed numerous grape-like cystic vesicles throughout the entire placenta and absence of trophoblastic proliferation and pseudoinclusions. We have described a pregnancy complicated with PMD associated with mid-trimester severe preeclampsia, IUGR and oligohydroamnios.

Keyword

Placental mesenchymal dysplasia; Pre-eclampsia

MeSH Terms

Fetal Growth Retardation
Fetus
Gestational Age
Placenta
Pre-Eclampsia
Pregnancy
Trophoblasts

Figure

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  Fig. 1 Transabdominal ultrasound examinations at (A), (B) 16 weeks and showing a thickened placenta with multiple, variable sized cysts, no blood flow signal within the mass.

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  Fig. 2 The delivered placenta. The placental parenchyma shows numerous grape-like cystic vesicles (arrows) throughout the entire placenta.

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  Fig. 3 Microscopic section of the placenta. (A) Enlarged stem villi shows loose myxoid stroma with occasioanl cisterns (arrows) (H&E, ×40). (B) The villous vessels are partially or completely oblierated with thrombi and fibrin deposit (arrows) (H&E, ×100).

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