Korean J Obstet Gynecol.  2011 Jun;54(6):326-329. 10.5468/KJOG.2011.54.6.326.

Vulvar neurilemmoma at the labium minus

• Kim NR
• Cho HY
• Lee SH

• KMID: 2274044
• DOI: http://doi.org/10.5468/KJOG.2011.54.6.326

Abstract

Neurilemmoma is a benign slow-growing nerve sheath neoplasm that is rarely found in the female genital system. To date, thirteen cases of vulvar neurilemmoma have been reported in the world literature. We report here on the first Korean case of vulvar neurilemmoma. A 43-year-old woman presented with a 0.6x0.6 cm sized oval nodule at the left labium minus. Complete excision was done. Microscopically, the mass was a well circumscribed lesion that was alternatively composed of cellular Antoni A and paucicellular Antoni B areas; The Antoni A areas were composed of spindle cells with twisted, buckled nuclei and occasional intranuclear vacuoles, and the spindle cells were arranged in short bundles or fascicles. Immunohistochemically, the spindle cells were positive for S100 protein and negative for desmin. Although it has a very low incidence, neurilemmoma should be considered in the differential diagnosis of a cutaneous or subcutaneous mass in the vulva.

Keyword

Neurilemmoma; Vulva; S100 proteins

MeSH Terms

Adult
Desmin
Diagnosis, Differential
Female
Humans
Incidence
Nerve Sheath Neoplasms
Neurilemmoma
S100 Proteins
Vacuoles
Vulva
Desmin
S100 Proteins

Figure

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  Fig. 1 (A) Low power view reveals a well circumscribed subcutaneous mass (H&E, ×40). (B) In a densely cellular Antoni A area, nuclear palisadings with Verocay bodies are seen. Note the hyalinized blood vessels are found in a paucicellular Antoni B area (arrow, H&E, ×200).

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