Korean J Obstet Gynecol.  2011 Jun;54(6):326-329. 10.5468/KJOG.2011.54.6.326.

Vulvar neurilemmoma at the labium minus

  • 1Department of Pathology, Gachon University Gil Hospital, Incheon, Korea.
  • 2Department of Obstetrics and Gynecology, Gachon University Gil Hospital, Incheon, Korea. miracle627@gilhospital.com


Neurilemmoma is a benign slow-growing nerve sheath neoplasm that is rarely found in the female genital system. To date, thirteen cases of vulvar neurilemmoma have been reported in the world literature. We report here on the first Korean case of vulvar neurilemmoma. A 43-year-old woman presented with a 0.6x0.6 cm sized oval nodule at the left labium minus. Complete excision was done. Microscopically, the mass was a well circumscribed lesion that was alternatively composed of cellular Antoni A and paucicellular Antoni B areas; The Antoni A areas were composed of spindle cells with twisted, buckled nuclei and occasional intranuclear vacuoles, and the spindle cells were arranged in short bundles or fascicles. Immunohistochemically, the spindle cells were positive for S100 protein and negative for desmin. Although it has a very low incidence, neurilemmoma should be considered in the differential diagnosis of a cutaneous or subcutaneous mass in the vulva.


Neurilemmoma; Vulva; S100 proteins

MeSH Terms

Diagnosis, Differential
Nerve Sheath Neoplasms
S100 Proteins
S100 Proteins


  • Fig. 1 (A) Low power view reveals a well circumscribed subcutaneous mass (H&E, ×40). (B) In a densely cellular Antoni A area, nuclear palisadings with Verocay bodies are seen. Note the hyalinized blood vessels are found in a paucicellular Antoni B area (arrow, H&E, ×200).


1. Weiss SW, Goldblum JR. Weiss SW, Goldblum JR, editors. Benign tumors of peripheral nerves. Enzinger and Weiss's soft tissue tumors. 2008. 5th ed. Philadelphia (PA): Mosby;825–901.
2. Fong KL, Bouwer H, Baranyai J, Jones RW. Ancient schwannoma of the vulva. Obstet Gynecol. 2009. 113:510–512.
3. Huang HJ, Yamabe T, Tagawa H. A solitary neurilemmoma of the clitoris. Gynecol Oncol. 1983. 15:103–110.
4. Woodruff JM, Marshall ML, Godwin TA, Funkhouser JW, Thompson NJ, Erlandson RA. Plexiform (multinodular) schwannoma. A tumor simulating the plexiform neurofibroma. Am J Surg Pathol. 1983. 7:691–697.
5. Yamashita Y, Yamada T, Ueki K, Ueki M, Sugimoto O. A case of vulvar schwannoma. J Obstet Gynaecol Res. 1996. 22:31–34.
6. Hanafy A, Lee RM, Peterson CM. Schwannoma presenting as a Bartholin's gland abscess . Aust N Z J Obstet Gynaecol. 1997. 37:483–484.
7. Quesada G, Solera JC, Sanchez-Baartolome J, Vazquez F, Lopez-Garcia L. Benign schwannoma of the vulva: a case report. J Gynecol Surg. 1998. 14:195–198.
8. Santos LD, Currie BG, Killingsworth MC. Case report: plexiform schwannoma of the vulva. Pathology. 2001. 33:526–531.
9. Llaneza P, Fresno F, Ferrer J. Schwannoma of the clitoris. Acta Obstet Gynecol Scand. 2002. 81:471–472.
10. Fujimoto E, Onishi Y, Tajima S, Okura T. Vulvar schwannoma. Rinsho Derma. 2004. 46:548–549.
11. Agaram NP, Prakash S, Antonescu CR. Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety. Am J Surg Pathol. 2005. 29:1042–1048.
12. Chuang WY, Yeh CJ, Jung SM, Hsueh S. Plexiform schwannoma of the clitoris. APMIS. 2007. 115:889–890.
13. Yegane RA, Alaee MS, Khanicheh E. Congenital plexiform schwannoma of the clitoris. Saudi Med J. 2008. 29:600–602.
14. Das S, Kalyani R, Kumar ML. Vulvar schwannoma: a cytological diagnosis. J Cytol. 2008. 25:108–110.
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