Korean J Obstet Gynecol.  2010 Jun;53(6):497-505. 10.5468/kjog.2010.53.6.497.

The predictive efficacy of maternal serum CA125 in intrauterine early pregnancy with vaginal bleeding

  • 1Department of Obstetrics and Gynecology, Hallym University College of Medicine, Seoul, Korea. obgyn25@hallym.or.kr


To investigate whether sudden rise or already increased level of maternal serum CA125 predicts spontaneous abortion in early pregnancy with vaginal bleeding. And if so, to decide the CA125 cut-off level for poor pregnancy outcomes.
The prospective study was performed in forty women presenting with any vaginal bleeding at early pregnancy. Maternal serum CA125 levels were evaluated on the first visit and followed up during the first trimester, or until the time to diagnose abortion. Serial maternal serum beta-hCG and ultrasonographic evaluation were also performed at the same time.
There were eventually fourteen abortions and twenty-six ongoing pregnancies. Using receiver-operating characteristic curve, 150 U/mL of serum CA125 was the most useful value for predicting spontaneous abortion. In most of abortion women, the serum CA125 level was increased over than 150 U/mL immediately before the abortion. The twelve of 17 women who were 150 U/mL or more resulted in abortion, while there were just two cases of abortion among 23 women who were less than 150 U/mL. Its positive predictive value was 70.6% and negative predictive value was 91.3% respectively (P<0.01).
There was a strong correlation between high level of serum CA125 and subsequent spontaneous abortion in early pregnancy. It should be valuable to check maternal serum CA125 added to beta-hCG and ultrasound for predicting pregnancy outcome at the early pregnancy, especially in the cases with vaginal bleeding.


CA125; Prediction; Pregnancy outcome; Abortion
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