Insulin-like Growth Factor Binding Protein-1 ( IGF-BP-1 ) in Maternal Serum of Women with Pregnancy Induced Hypertension

Yoo, Y K; Cho, J S; Choi, H M; Lee, Y H; Park, Y W

Abstract

IGF-BP-1 is known to have a important role in fetal growth and development by modulation of the actions of IGF, but also has its independent actions and in vitro IGF- BP-1 inhibits cytotrophoblastic invasion into decidualized stromal multilayers. The goals of this study are to investigate the IGF-BP-1 in maternal serum of women with pregnancy induced hypertension and without and evaluate the relationship between IGF-BP-1 of maternal serum and intrauterine growth restriction. IGF-BP-1 levels in maternal serum with pregnacy induced hypertension were 183.5+/-46.3 ng/ml compared with 148.9+/-44.3 ng/ml in controls (p<0.01). IGF-BP-1 levels in maternal serum with pregnancy induced hypertension and intrauterine growth restriction were 199.1+/-44.8 ng/ml compared with 167.1+/-42.2 ng/ml in maternal serum with pregnancy induced hypertension but without intrauterine growth restriction. In conclusion, elevated maternal serum IGF-BP-1 levels may contribute to restricted placental and therefore fetal growth.