Influence of progestrone receptor and vascularity in leiomyoma to the growth and clinical symptoms

Hwang, Sung Jin; Moon, Young Ju; Jung, In Chul; Kim, Mee Ran; Kwun, Dong Jin; Lim, Young Taek; Kim, Jang Heub; Cho, Hyun Hee; Kim, Jin Hong

Abstract

OBJECTIVE
Myoma is the most frequent benign tumor in women's pelvic cavity. Myoma causes a lot of symptoms that degrade the life quality of the patients. If the patient with leiomyoma does not require the treatment, regular follow-up is recommended. However, there is no definite method to predict the clinical outcome of leiomyoma patients. So we evaluate if the hormone receptors and vascular viability can predict the clinical outcomes in leiomyoma patients.
METHODS
We perform the leiomyoma biopsy and ultrasonogram in leiomyoma patients who are symptomatic, premenopaused, and unnecessary to receive treatment. The patients were grouped into two as the results of progesterone receptor status of leiomyoma ; strong positive (> or = 75% positive to progesterone receptor), trace and negative (<25% positive to progesterone receptor). Also, we evaluates the vascular state and the resistance index (RI) of feeding arteries of myoma with doppler ultrasonogram. The severities of clinical symptoms are interpreted by using Uterine fibroid symptom and health-related quality of life questionnaire (UFS-QOL).
RESULTS
After 8 months, the strong positive group shows the greater increasement of myoma volume than the trace and negative group. Also, the patient's symptoms and scores of life-quality decrease in strong positive group. In contrast, the trace and negative group show the improvement in clinical symptoms and life-quality.
CONCLUSION
As a result, we concluded the status of hormonal receptor and feeding arteries can predict the clinical change of leiomyoma.