Korean J Obstet Gynecol.  2009 Jan;52(1):68-74.

Ultrasound-guided local injection of potassium chloride (KCl) and methotrexate (MTX) in the treatment of cornual pregnancy

• Park HR
• Moon MJ
• Shin SJ
• Jang SW
• Ahn EH
• Jung SH
• Shim SS
• Kang SH
• Kim HC
• Hwang YY
• Baek MJ

Abstract

OBJECTIVE
To evaluate efficacy and safety of local injection of potassium chloride (KCl) and methotrexate (MTX) in the treatment of cornual pregnancy.
METHODS
We retrospectively reviewed all cases of cornual pregnancy treated conservatively from 2005 through August 2007. Eight cases were identified and two cases were heterotopic interstitial pregnancy. All cases were managed with local injection of KCl or methotrexate under ultrasound guidance and 2 cases were treated with intra-muscular injection of MTX in combination. After the procedure all cases with cardiac activity was confirmed to be aborted by ultrasound. Also serial follow-up sonographic examination and serum beta-hCG measurement were performed.
RESULTS
The mean initial beta-hCG level was 53,331.6 mIU/mL and ranged from 14,332 mIU/mL to 125,721 mIU/mL. Mean gestational age was 48.3 days from 40 to 65 days. All cases were aborted successfully and follow up beta-hCG were declined abruptly. Two cases of heterotopic pregnancy resulted in successful deliveries at full term.
CONCLUSION
Cornual resection or hysterectomy should no longer be the first line of treatment for hemodynamically stable patients with cornual pregnancy. They can be successfully treated through local injection of MTX or KCl by ultrasound guidance.

Keyword

Cornual pregnancy; Heterotopic pregnancy; Ultrasound guidance; Local injection

MeSH Terms

Follow-Up Studies
Gestational Age
Humans
Hysterectomy
Methotrexate
Potassium
Potassium Chloride
Pregnancy
Pregnancy, Heterotopic
Retrospective Studies
Methotrexate
Potassium
Potassium Chloride