Korean J Obstet Gynecol.  2008 Nov;51(11):1337-1341.

A case of Larsen syndrome

Affiliations
  • 1Department of Obstetrics & Gynecology, Eulji University Hospital, Daejeon, Korea. ohky5@eulji.ac.kr

Abstract

Larsen syndrome is a rare congenital skeletal malformation (1 in 100,000 births) caused by a generalized mesenchymal connective tissue disorder. This disorder leads to a broad spectrum of anomalies. Major diagnostic criteria are multiple dislocations of large joints (especially knees), short metacarpals with cylindrical nontapering fingers and craniofacial abnormalities. Clinical variations range from mild clinical expression to lethal forms. Sporadic occurrence as well as autosomal dorminant and recessive inheritance are described.

Keyword

Larsen syndrome

MeSH Terms

Connective Tissue
Craniofacial Abnormalities
Dislocations
Fingers
Joints
Metacarpal Bones
Methapyrilene
Wills
Methapyrilene
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