Korean J Obstet Gynecol.  2008 Nov;51(11):1288-1294.

The immunohistochemical study on Ki-67 Expression in epithelial ovarian carcinomas

• Park CM
• Han SY
• Kim I
• Kim HC
• Kang JS

Abstract

OBJECTIVE
The study was to evaluate the biological significance of Ki-67 expression in common epithelial ovarian carcinomas. We investigated the correlation between Ki-67 expression and clinicopathological parameters.
METHODS
One hundred patients with epithelial ovarian carcinomas stage I-IV treated at Department of Obstertrics and Gynecology, Korea University Hospital from January 1994 to December 2004 were used as study group. We determined expression of Ki-67 by immunohistochemistry using MIB-1 monoclonal antibody reactivity.
RESULTS
Ki-67 overexpression was higher in high stage (III-IV) than low stage (I-II) (P<0.013). Ki-67 overexpression was higher in serous cystadenocarcinoma (76.3%) than mucinous cystadenocarcinoma (53.6%), endometrioid carcinoma (54.5%) and clear cell carcinoma (58.3%) but it was not statistically significant (P<0.191). Ki-67 expression was higher in high grade but it was not statistically significant (P<0.096). Ki-67 overexpression was not correlated with serum CA-125 level (P<0.172). Overall survival revealed significant survival difference between patients whose tumor showed Ki-67 overexpressions compared with remaining patients.
CONCLUSIONS
Ki-67 overexpressions was a poor prognostic indicator in epithelial ovarian carcinomas.

Keyword

Ki-67 antigen; Immunohistochemistry; Ovary; Carcinoma

MeSH Terms

Antibodies, Antinuclear
Antibodies, Monoclonal
Carcinoma, Endometrioid
Cystadenocarcinoma, Mucinous
Cystadenocarcinoma, Serous
Female
Gynecology
Humans
Immunohistochemistry
Ki-67 Antigen
Korea
Ovary
Antibodies, Antinuclear
Antibodies, Monoclonal
Ki-67 Antigen