Korean J Obstet Gynecol.  2007 Jan;50(1):142-148.

The efficacy and safety of the combined preparation of Black Cohosh and St. John's wort in menopausal women

• Park HB
• Kang YD
• Cho HC
• Lee WK
• Park JW

Abstract

OBJECTIVE
The aim of this study was to assess the efficacy and safety of the combined preparation of black cohosh and St. John's wort (GYNO-Plus(R)) in post menopausal women with symptoms.
METHODS
A total number of 60 postmenopausal women with climacteric symptoms was allocated to take GYNO-Plus(R) for 3 months. And the change of the Kupperman menopausal index (KI), serum FSH and E2 level, bone densitometry (BMD), mammographic density, liver function test (LFT) and adverse effects were assessed.
RESULTS
There was statistical difference in the decline of KI after 3 months treatment. But, there were no statistical differences in the change of serum FSH and E2 level, BMD, mammographic density, and LFT. There were nine adverse events in study, but two cases were directly related to the drug and they were resolved without any sequela.
CONCLUSION
This study suggests that the combined preparation of black cohosh and St. John's wort is a safe, effective alternative treatment option for patients in whom hormone replacement therapy is either refused or contraindicated.

Keyword

menopause; Black cohosh; St. John's wort; efficacy; safety

MeSH Terms

Cimicifuga*
Climacteric
Densitometry
Female
Hormone Replacement Therapy
Humans
Hypericum*
Liver Function Tests
Menopause