Korean J Obstet Gynecol.  2007 Jan;50(1):135-141.

Clinical value of serum vascular endothelial growth factor (VEGF) in ovarian diseases

• Yoon JH
• Kim DH
• Lew YO

Abstract

OBJECTIVE
The aim of this study was to evaluate the concentration of serum VEGF and its relationship with the clinical parameters and the tumor markers in ovarian diseases.
METHODS
We measured the serum VEGF concentrations by ELISA in 76 patients with benign ovarian disease, as well as 9 normal volunteers, 4 patients with ovarian borderline malignancy and 53 patients with ovarian cancer.
RESULTS
There is a significant statistical difference between the serum VEGF levels in patients with benign ovarian disease (157.7+/-197.8 pg/ml) and ovarian cancer (344.7+/-372.2 pg/ml) (p<0.005).
CONCLUSION
Serum VEGF may help in the differential diagnosis between benign and malignant ovarian disease. We suggest that serum VEGF may be useful as a diagnostic tool in ovarian disease.

Keyword

Ovarian disease; VEGF

MeSH Terms

Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Female
Healthy Volunteers
Humans
Ovarian Diseases*
Ovarian Neoplasms
Biomarkers, Tumor
Vascular Endothelial Growth Factor A*
Vascular Endothelial Growth Factor A