Ann Rehabil Med.  2015 Apr;39(2):268-276. 10.5535/arm.2015.39.2.268.

Factors Associated With Upper Extremity Motor Recovery After Repetitive Transcranial Magnetic Stimulation in Stroke Patients

• Lee JH
• Kim SB
• Lee KW
• Kim MA
• Lee SJ
• Choi SJ

• KMID: 2273049
• DOI: http://doi.org/10.5535/arm.2015.39.2.268

Abstract

OBJECTIVE
To determine factors associated with motor recovery of the upper extremity after repetitive transcranial magnetic stimulation (rTMS) treatment in stroke patients.
METHODS
Twenty-nine patients with subacute stroke participated in this study. rTMS was applied to the hand motor cortex for 10 minutes at a 110% resting motor threshold and 10 Hz frequency for two weeks. We evaluated the biographical, neurological, clinical, and functional variables, in addition to the motor-evoked potential (MEP) response. The Manual Function Test (MFT) was performed before, immediately after, and two weeks after, the treatment. Patients were divided into a responder and non-responder group according to their respective improvements on the MFT. Data were compared between the two groups.
RESULTS
Patients with exclusively subcortical stroke, absence of aphasia, the presence of a MEP response, high scores on the Mini-Mental Status Examination, Motricity Index arm score, Functional Independence Measure, and Functional Ambulatory Classification; and a shorter period from stroke onset to rTMS were found to be significantly associated with a response to rTMS.
CONCLUSION
The results of this study suggest that rTMS may have a greater effect on upper extremity motor recovery in stroke patients who have a MEP response, suffer an exclusively subcortical stroke, mild paresis, and have good functional status. Applying rTMS early would have additional positive effects in the patients with the identified characteristics.

Keyword

Stroke; Transcranial magnetic stimulation; Motor function

MeSH Terms

Aphasia
Arm
Classification
Hand
Humans
Motor Cortex
Paresis
Stroke*
Transcranial Magnetic Stimulation*
Upper Extremity*

Figure

• 

  Fig. 1 Patients were classified into two groups according to their improvements in Manual Function Test either immediately after or two weeks after rTMS. MCID, minimal clinically important difference; rTMS, repetitive transcranial magnetic stimulation.

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