Korean J Obstet Gynecol.  2005 Apr;48(4):969-977.

Estrogen Receptor Gene PvuII and XbaI Polymorphisms and Ultrasonographic Findings of Uterine Endometrium in Postmenopausal Women with Hormone Replacement Therapy

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea. seokhyun@snu.ac.kr
  • 2Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea.

Abstract


OBJECTIVE
To explore the association of estrogen receptor (ER) alpha gene PvuII and XbaI polymorphisms and ultrasonographic findings of uterine endometrium.
METHODS
Forty-five postmenopausal women undergoing hormone replacement therapy (HRT) were included in this study. Women were evaluated for PvuII and XbaI polymorphisms for ER alpha gene after extracting DNA from peripheral blood. The thickness and appearance of uterine endometrium was measured by transvaginal ultrasonography. The association of estrogen receptor gene PvuII and XbaI polymorphisms and ultrasonographic endometrial findings were analyzed.
RESULTS
No statistically significant difference was found in endometrial thickness (pp 3.6 +/- 1.5 mm, Pp 4.2 +/- 1.6 mm, PP 3.5 +/- 1.3 mm) or endometrial appearance among the three different groups by PvuII polymorphism. No significant difference was also observed in endometrial thickness (xx 3.6 +/- 1.5 mm, Xx 4.2 +/- 1.4 mm) or endometrial appearance between the two groups of different XbaI genotypes.
CONCLUSION
These results suggest that neither PvuII nor XbaI polymorphism of the estrogen receptor alpha gene may be associated with the ultrasonographic findings of uterine endometrium in postmenopausal women undergoing HRT. Further studies with a larger scale are necessary to confirm these data.

Keyword

Postmenopausal women; Hormone replacement therapy (HRT); Estrogen receptor (ER) gene; Polymorphism; PvuII; XbaI; Endometrium; Ultrasonography
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