Korean J Obstet Gynecol.  2005 Feb;48(2):480-483.

A case of prenatally diagnosed Non-15, Non-22 marker chromosome

Affiliations
  • 1Department of Obstetics and Gynecology, Sun Genenal Hospital, Daejeon, Korea. mdsong@hanmail.net
  • 2Department of Laboratory Medicine, Sun Genenal Hospital, Daejeon, Korea.

Abstract

Midtrimester genetic amniocentesis is an important diagnostic tool in prenatal genetic diagnosis and counseling. We can identify karyotypes with metaphase chromosome analysis of cultured amniocytes. Marker chromosomes are defined as unidentified structurally abnormal chromosomes. Incidence of marker chromosomes in the previous reported studies was 0.6-1.5/1,000. They occurred more frequently with advanced maternal age. Ascertainment of chromosomal origin is important because it may be associated with malformation and developmental abnormalities. Recently, identification of the origin and composition of marker chromosomes has been made possible by the use of fluorescent in situ hybridization (FISH). Most marker chromosomes are known to be originated from chromosome 15 or 22, X, Y. We have experienced a case of non-15, non-22 marker chromosome prenatally detected in amniocentesis and FISH, so we reported it with a brief review of literature.

Keyword

Marker chromosome; Amniocentesis; FISH

MeSH Terms

Amniocentesis
Chromosomes, Human, Pair 15
Counseling
Diagnosis
Female
Humans
In Situ Hybridization, Fluorescence
Incidence
Karyotype
Maternal Age
Metaphase
Pregnancy
Pregnancy Trimester, Second
Full Text Links
  • KJOG
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr