Korean J Obstet Gynecol.  2005 Feb;48(2):418-427.

Survivin and Bcl-2 expression in eutopic endometrium with and without endometriosis

• Kim YJ
• Kim YA
• Kim HS
• Suh WH
• Kim KK
• Chang DY
• Jeon MK
• Lee ES

Abstract

OBJECTIVE
To examine expression of survivin and Bcl-2 in eutopic endometrium with endometriosis and without endometriosis by immunohistochemical stain.
METHODS
Expression of survivin and Bcl-2 was immunohistochemically investigated in eutopic endometrium with endometriosis (n=30, study group I; laparoscopy-proved endometriosis, study group II; adenomyosis) or without endometriosis (n=34, control group). The score of immunohistochemical staining was evaluated semi-quantitative method modified by Sinicrope and Lu. Statistical analyses was carried out using one-way ANOVA with Turkey test.
RESULTS
Survivin expression was significantly higher in nucleus of glandular epithelium of eutopic endometrium with endomtriosis compared to that without endometriosis (p<0.05). Increased expression of Bcl-2 was found in glandular epithelium of eutopic endometrium with endometriosis than without endometriosis, but there was no significantly difference.
CONCLUSION
Our findings suggest that increased survivin expression may contribute to survival of endometriosis. Moreover, survivin could play an important role in pathogenesis of endometriosis.

Keyword

Endometriosis; Eutopic endometrium; Survivin; Bcl-2

MeSH Terms

Endometriosis*
Endometrium*
Epithelium
Female
Turkey