Positive Margins after Cervical Conization and the Predictive Factors of Residual Disease

Song, Seung Hun; Lee, Eun Sung; Lee, Jae Kwan; Oh, Min Jung; Hur, Jun Young; Park, Yong Kyun; Saw, Ho Suk

Abstract

OBJECTIVE
The aim of this study was to evaluate the predictive factors of residual disease for positive conization margins.
METHODS
Retrospective study was performed in 735 patients treated with bovie electroknife conization at the University Hospital of Kuro between January, 1988 and December, 2003. Of the 735 patients, 81 patients (11.0%) had positive margins after conization. 58 of these 81 patients underwent either immediate reoperation or monitoring with a Pap smear, HPV test, endocervical curettage and colposcopy. Fisher exact test, Trend test were used for statistical analysis.
RESULTS
The mean age of the patients was 44.5 years. 27 of 58 patients (46.6%) undergoing conization followed by reoperation had residual lesion in the specimen obtained by reoperation. Severity of lesion was associated with the predictive factors of residual disease (p<0.05). Age of patients, site of resection margins were not associated with the predictive factors of residual disease. But more sufficient number of cases of Pap smear, HPV test, endocervical curettage and colposcopy directed biopsy are thought to be needed for stastistical analysis.
CONCLUSION
Severity of lesion is useful in predicting residual disease for positive conization margins.