Factors Affecting Normal Pubertal Development after bone Marrow Transplantation in Girls

Jo, Hyun Hee; Kim, Mee Ran; Kwon, Dong Jin; Kim, Jang Heub; Sung, In Kyung; Kim, Jin Hong

Abstract

OBJECTIVE
To evaulate the factors affecting pubertal development after bone marrow transplantation (BMT) in girls.
METHODS
We collected data from girls older than 14 on 2003, who had received bone marrow transplantation with or without total body irradiation. We checked their menstrual pattern, onset of menarche, growth rate before and after the transplantation using chart review.
RESULTS
41.6% of girls who took menarche before BMT mensurate regularly and 100% of girls who didn't take menarche before BMT suffered by amenorrhea. Time period from BMT to menarche is 0.6 years in the regular-menstruating group, and 2.14 years in the secndary amenorrhea group. 37.5% of girls who didn't take total body irradiation menstrate regularly, but only 15.3% of girls who took total body irradiation menstrate regularly. 100% of girls who showed decreasing growth rate after BMT diagnosed primary or secondary amenorrhea and 75% of girls showed increasing growth rate after BMT menstrated regularly.
CONCLUSION
Ovary is more vulnerable before menarche. Time of menarche, time period between menarche and BMT, and radiation are the most important factors affecting ovarian function after bone marrow transplantation.