Korean J Obstet Gynecol.  2003 Feb;46(2):410-422.

The Effects of Green Tea Extracts (Polyphenon E, EGCG) in Human Papilloma Virus Positive Cervical Lesion

• Ko HS
• Huh SW
• Bae SM
• Son SA
• Chung JE
• Jin DK
• Lee IS
• Sin JI
• Lee JM
• Namkoong S
• Ahn WS

Abstract

OBJECTIVE
We tried to confirm the effects of green tea extracts (polyphenon E, EGCG) in patients with human papilloma virus (HPV) positive cervical lesion.
METHODS
We divided 51 HPV positive cervical lesion patients (chronic cervicitis, mild dysplasia, moderate dysplasia and severe dysplasia) into 4 group and 37 patient as placebo control. We applied poly E ointment two times per week (27 patients), poly E ointment plus poly E capsule (8 patients), poly E capsule (6 patients), EGCG capsule (10 patients) 200 mg each for 8 to 12 weeks.
RESULTS
Among 27 patients with poly E ointment group, 20 patients responded (74%), such as chronic cervicitis (12/18), mild dysplasia (4/5), moderate dysplasia (2/2) and severe dysplasia (1/2). Among 8 patients with poly E ointment and poly E capsule group, 6 patients responded (75%), 6 patients poly E capsule group responded 3 patients (50%). 10 EGCG capsule patients group responded 6 patients (60%). Overall responsive rate is 69% (35/51) in case of green tea extracted treated group and 10% (4/39) in placebo controlled group (P<0.05).
CONCLUSION
The effects of green tea extract in HPV positive cervical lesion were statistically significant (P<0.05). This result suggests that green tea extract has highly potential of new treatment agent for HPV infected cervical lesion.

Keyword

Green tea Extracts; EGCG; Polyphenon E; Cervical Cancer; HPV

MeSH Terms

Humans*
Papilloma*
Tea*
Uterine Cervical Neoplasms
Uterine Cervicitis
Tea