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Clinical Information on Green Tea Extract Used for Weight Loss

Youn Y, Shin S, Jeong KH, Lee E

BACKGROUND: Green tea extracts are approved as nonprescription drug and available as health functional foods, health foods, and beverages. Clinical information on the products is lacking. METHODS: Information about the products...
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Histomorphometric evaluation of bone healing capacity of epigallocatechin-3-gallate-loaded β-TCP bone substitute in rabbit calvarial defects

Park JW

This study investigated the effect of epigallocatechin-3-gallate (EGCG)-loaded microporous β-tricalcium phosphate (β-TCP) bone substitute in the bone healing of rabbit calvarial defects. New bone formation induced by β-TCP incorporating two...
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In vitro Effects of Epigallocatechin Gallate on Sister Chromatid Exchange in the Lymphocytes Exposed to Glyphosate

Park JM, Choi WI, Jin SC, Lee JH, Choi IJ

PURPOSE: Green tea is known as a potent anti-oxidant, anti-carcinogen, and genetic protector. Glyphosate (N-phosphonomethyl glycine) is a widely used non-selective herbicide that causes DNA damage. The present study was...
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Four-week histologic evaluation of grafted calvarial defects with adjunctive hyperbaric oxygen therapy in rats

Chang H, Oh SE, Oh S, Hu KS, Kim S

PURPOSE: The aim of this study was to characterize the healing in the grafted calvarial defects of rats after adjunctive hyperbaric oxygen therapy. METHODS: Twenty-eight male Sprague-Dawley rats (body weight, 250–300...
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Epigallocatechin-3-Gallate (EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative Stress

Zhang B, Wang B, Cao S, Wang Y

Traumatic brain injury (TBI) is a major cause of mortality and long-term disability, which can decrease quality of life. In spite of numerous studies suggesting that Epigallocatechin-3-gallate (EGCG) has been...
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Primary Cancer Prevention by Green Tea, and Tertiary Cancer Prevention by the Combination of Green Tea Catechins and Anticancer Compounds

Fujiki H, Sueoka E, Watanabe T, Suganuma M

Green tea is a daily beverage, a non-oxidized non-fermented product containing at least four green tea catechins. Considering our first results when repeated applications of (-)-epigallocatechin gallate (EGCG) prevented tumor...
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Antiallodynic effect of intrathecal epigallocatechin-3-gallate due to suppression of reactive oxygen species

An SS, Kim YO, Park CH, Lin H, Yoon MH

BACKGROUND: Green tea modulates neuropathic pain. Reactive oxygen species (ROS) are suggested as a key molecule in the underlying mechanism of neuropathic pain in the spinal cord. We examined the...
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Anti-obesity effect of EGCG and glucosamine-6-phosphate through decreased expression of genes related to adipogenesis and cell cycle arrest in 3T3-L1 adipocytes

Kim KB, Jang SH

  • KMID: 2327454
  • J Nutr Health.
  • 2014 Feb;47(1):1-11.
PURPOSE: Several studies have proven that EGCG, the primary green tea catechin, and glucosamine-6-phosphate (PGlc) reduce triglyceride contents in 3T3-L1 adipocytes. The objective of this study is to evaluate the...
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Reversal of Cisplatin Resistance by Epigallocatechin Gallate Is Mediated by Downregulation of Axl and Tyro 3 Expression in Human Lung Cancer Cells

Kim KC, Lee C

Lung cancer is still the number one cause of death from cancer worldwide. The clinical effect of platinum-based chemotherapy for non-small cell lung cancer is constrained by the resistance to...
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Inhibitory Effects of Epigallocatechin-3-Gallate on Microsomal Cyclooxygenase-1 Activity in Platelets

Lee DH, Kim YJ, Kim HH, Cho HJ, Ryu JH, Rhee MH, Park HJ

  • KMID: 2170686
  • Biomol Ther.
  • 2013 Jan;21(1):54-59.
In this study, we investigated the effect of (-)-epigallocatechin-3-gallate (EGCG), a major component of green tea catechins from green tea leaves, on activities of cyclooxygenase (COX)-1 and thromboxane synthase (TXAS),...
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Effect of EGCG on Expression of Neurogenin 3 via the MAP Kinase Signaling Pathway in AR42J Cells, a Rat Pancreatic Tumor Cell Line

Kim SO, Choe WK

Epigallocatechin gallate (EGCG), or epigallocatechin 3-gallate, is the ester of epigallocatechin and gallic acid, and is a type of catechin. EGCG may be therapeutic for many disorders including diabetics and...
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Epigallocatechin-3-gallate Regulates Inducible Nitric Oxide Synthase Expression in Human Umbilical Vein Endothelial Cells

Ahn HY, Kim CH

Inducible nitric oxide synthase (iNOS) is a main enzyme producing nitric oxide during inflammation and thus contributes to the initiation and development of inflammatory cardiovascular diseases such as atherosclerosis. Epigallocatechin-3-gallate...
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Epigallocatechin-3-gallate Regulates NADPH Oxidase Expression in Human Umbilical Vein Endothelial Cells

Ahn HY, Kim CH, Ha TS

Vascular NADPH oxidase plays a pivotal role in producing superoxide in endothelial cells and thus acts in the initiation and development of inflammatory cardiovascular diseases such as atherosclerosis. Epigallocatechin-3-gallate (EGCG),...
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A Case of Green Tea-induced Occupational Asthma

  • KMID: 2346814
  • Korean J Asthma Allergy Clin Immunol.
  • 2009 Dec;29(4):298-301.
Tea is one of the most widely consumed beverages in the world. Green tea-induced occupational asthma among green tea factory workers is caused by inhalation of tea dust. Epigallocatechin gallate...
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The Effect of Epigallocatechin-3-gallate on HIF-1alpha and VEGF in Human Lung Cancer Cell Line

Song JH, Jeon EJ, Kwak HW, Lee HM, Cho SG, Kang HK, Park SW, Lee JH, Lee BO, Jung JW, Choi JC, Shin JW, Kim KJ, Kim JY, Park IW, Choi BW

BACKGROUND: Epigallocatechin-3-gallate (EGCG) is the major catechin in green tea, and has shown antiproliferative, antiangiogenic, antimetastatic and cell cycle pertubation activity in various tumor models. Hypoxia can be induced because...
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Lack of EGCG Effects on Radiation-Induced Apoptosis of Mice Splenocytes

Jang SS, Lee HK

PURPOSE: The modification of radiation-induced apoptosis by EGCG, known as antioxidants or oxidants, was studied in mice spleens irradiated with a lethal dose. MATERIALS AND METHODS: Male C57BL/6 mice were...
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Protective Effects of Epigallocatechin Gallate After UV Irradiation of Cultured Human Lens Epithelial Cells

Heo J, Lee BR, Koh JW

PURPOSE: To evaluate the protective effects of epigallocatechin gallate (EGCG) against UV irradiation of cultured human lens epithelial cells. METHODS: We irradiated cultured human lens epithelial cells with...
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(-)-Epigallocatechin Gallate Inhibits the Pacemaker Activity of Interstitial Cells of Cajal of Mouse Small Intestine

Kim KY, Choi SJ, Jang HJ, Zuo DC, Shahi PK, Parajuli S, Yeum CH, Yoon PJ, Choi S, Jun JY

The effects of (-)-epigallocatechin gallate (EGCG) on pacemaker activities of cultured interstitial cells of Cajal (ICC) from murine small intestine were investigated using whole-cell patch-clamp technique at 30degrees C and...
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The Protective Effect of EGCG on INS-1 Cell in the Oxidative Stress and Mechanism

Kim MK, Jung HS, Yoon CS, Kwon MJ, Koh KS, Rhee BD, Park JH

BACKGROUND: Oxidative stress is important in both diabetic complications and the development and the progression of type 2 diabetes via the effects on the pancreatic beta-cells. EGCG (epigallocatechin galleate), a...
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Green Tea Extracts Inhibits HGF-Induced HNSCC Progression in vitro

Kim CH, Lim HJ, Kang SU, Lee HN, Hwang HS, Yoon YR, Kim DH

  • KMID: 2276850
  • Korean J Otorhinolaryngol-Head Neck Surg.
  • 2008 Feb;51(2):163-170.
BACKGROUND AND OBJECTIVES: Aberrant activation of hepatocyte growth factor (HGF) and its receptor, c-Met, has been known to be involved in many human cancer development and progression. During the search...
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