Korean J Occup Health Nurs.  2015 May;24(2):67-75. 10.5807/kjohn.2015.24.2.67.

Five Year's Follow-up of the Cardiovascular Disease Risk Factors among the Low Level Organic Solvent Exposure Workers

• Kim MA

• KMID: 2270657
• DOI: http://doi.org/10.5807/kjohn.2015.24.2.67

Abstract

PURPOSE
The objective of the present study was to evaluate the effects of occupational exposure to low dose organic solvents on the prevalence of cardiovascular risk factors.
METHODS
Study design was retrospective cohort study subjected on 191 exposures and 118 controls working in a petrochemical manufacture company. The eight indicators related to CVD risk were followed up for five years from 2008 to 2012. The risk level was compared during the follow up years and subject's characteristics, and the change of risk level were analyzed with repeated measures ANOVA and multiple logistic regression analysis.
RESULTS
At the start year 2008, the rate over cutoff value (ROCV) of BS (p<.001) and mean systolic BP (p=.017) were higher in organic solvent exposure group and the others showed no difference. And by the subject's characteristics, odds ratio of the ROCV of BS were higher in organic solvent exposure group and work shift group as 2.51 and 3.07. Comparing the results in 2012 to those of 2008, cardiovascular disease risk in organic solvent exposure group was about 1.5 times higher than that of in the control group.
CONCLUSION
Gradual increase in the CVD risk was identified in organic solvent exposure group. However, the risk might be influenced by shift work and bad behaviors rather than organic solvent exposure.

Keyword

Cardiovascular disease; Organic solvent; Low dose; 5 years follow-up

MeSH Terms

Cardiovascular Diseases*
Cohort Studies
Follow-Up Studies*
Logistic Models
Occupational Exposure
Odds Ratio
Prevalence
Retrospective Studies
Risk Factors*
Solvents
Solvents