The clinical value of serum TPS and CA 125 in the diagnosis of epithelial ovarian cancer

No, Jae Hong; Seo, Sang Soo; Kim, Yong Bum; Kim, Jae Won; Park, Noh Hyun; Song, Yong Sang; Kang, Soon Beom; Lee, Hyo Pyo

Abstract

OBJECTIVE
The purpose of this study is to evaluate and compare the usefulness of the serum levels of tissue polypeptide specific antigen (TPS) and CA 125 for the diagnosis of epithelial ovarian cancer.
MATERIALS AND METHODS
A total of 93 patients were included in this study. Of theses 51 proposed with epithelial ovarian cancer including 27 borderline malignant tumor, while 42 suffered from benign ovarian tumor. The levels of serum CA 125 and TPS was measured retrospectively in all patients using sera collected before surgery.
RESULTS
Elevated levels of TPS were detected in 56.9% (29/51) of patients with epithelial ovarian cancer and borderline malignancy and in 35.7% (15/42) of patients with benign ovarian tumor. Elevated levels of CA 125 were detected in 45.1% (23/51) of patients with epithelial ovarian cancer and borderline malignancy and in 14.3% (6/42) of patients with benign ovarian tumor. The detection rate for serous cancer was 81.0% (17/21) with TPS, and 71.4% (15/21) with CA 125. In mucinous cancer, the detection rate was 37.5% (9/24) with TPS, and 25.0% (6/24) with CA 125.
CONCLUSION
Determination of the level of TPS is useful for detection of epithelial cancer and borderline malignancy especially in mucinous tumor.