Korean J Obstet Gynecol.  2002 Jun;45(6):1092-1096.

Hyperreactio luteinalis associated with a normal singleton pregnancy

• Lee KB
• Kim GJ
• Hwang BC
• Cho HY

Abstract

Hyperreactio luteinalis is a rare disease characterized by marked cystic enlargement of the ovary due to multiple benign theca lutein cyst. The cause of this disease is not well known but is believed to be induced by high serum levels of human chorionic gonadotropins (hCG). It occurs usually in gestational trophoblastic disease, multiple pregnancies, and rarely in normal pregnancy. In nature, hyperreactio luteinalis is a benign condition. Therefore, the appropriate management is conservative, but surgical intervention is definitely indicated to remove infarcted tissue, control hemorrhage, or decrease androgen production in virilized patients. Here we report a case of hyperreactio luteinalis which was diagnosed at 11 weeks gestation. Lower abdominal pain was developed and progressed. Emergent right wedge oophorectomy and left salpingoophorectomy was performed due to probable torsion of left ovarian cyst and the pregnancy maintained. Theca lutein cysts were confirmed on pathologic examination.

Keyword

Hyperreactio luteinalis; hCG; Theca lutein cyst; Pregnancy

MeSH Terms

Abdominal Pain
Chorionic Gonadotropin
Female
Gestational Trophoblastic Disease
Hemorrhage
Humans
Lutein
Ovarian Cysts
Ovariectomy
Ovary
Pregnancy*
Pregnancy, Multiple
Rare Diseases
Chorionic Gonadotropin
Lutein