A Case of Complete Response in Locally Advanced Vulvar Cancer after Concomitant Chemoradiation Therapy

Han, Soo Yeon; Park, Noh Hyun; Wu, Hong Gyun; Roh, Ju Weon; Jeong, Hyeon Jeong; Kim, Jae Weon; Song, Yong Sang; Kang, Soon Beom; Lee, Hyo Pyo

Abstract

Cancer of the vulva accounts for approximately 0.5% of all gynecologic malignancies. At diagnosis, one-third of these cases is detected in an advanced stage (FIGO stages III, IV), and local extension of primary vulvar cancer may involve adjacent midline structures such as the clitoris, urethra, vagina, and anus. Initial surgical therapy of such locally advanced primary cancers may compromise the functional integrity of midline structures, necessitating ultraradical surgery including pelvic exenteration. In view of the relatively elderly age of the patients and the morbidity of this ultraradical dissection, concomitant chemoradiation therapy - that the efficacy had been proven in head and neck cancer, anal cancer has approached for patients with locally advanced vulvar cancer. We experienced a case of stage III vulvar cancer patient, who underwent concomitant chemoradiation therapy with 5-fluorouracil(FU) and cisplatin and who showed complete response. So, we report this case with brief review of the literatures.