Asian Oncol Nurs.  2015 Mar;15(1):9-17. 10.5388/aon.2015.15.1.9.

Factors Influencing Quality of Life in Multiple Myeloma Patients

  • 1College of Nursing, Graduate School of Seoul National University, Seoul, Korea.
  • 2College of Nursing & Research Institute of Nursing Science, Seoul National University, Seoul, Korea.


The purpose of the study was to investigate the relationships among fatigue, pain, anxiety, depression, and quality of life in Korean patients with multiple myeloma and to identify factors influencing their quality of life.
The study design was a crosssectional descriptive study. The participants were 92 multiple myeloma patients who visited the outpatient department at a university hospital in Seoul, Korea. The data were collected from January to April in 2013 with self-reporting questionnaires.
The mean scores of quality of life in all dimensions were relatively low. Fatigue, pain, anxiety and depression were all correlated to the global heath/quality of life, functional quality of life, and symptom quality of life (p<.001). Fatigue, pain and depression accounted for 65.1% (p<.001) in global health/quality of life and 73.6% (p<.001) in functional quality of life, respectively. And fatigue and pain accounted for 66.4% (p<.001) in symptom quality of life.
The results of the study showed that fatigue, pain and depression were major predictors of quality of life for patients with multiple myeloma. Therefore, psychological symptoms, such as depression, and physical symptoms should be integrated into the nursing intervention to improve their quality of life.


Quality of Life; Fatigue; Pain; Anxiety; Depression

MeSH Terms

Multiple Myeloma*
Quality of Life*
Surveys and Questionnaires

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1. National Cancer Information Center. Multiple myeloma. Accessed August 1, 2012.
2. National Cancer Center. Anual report of cancer statistics in Korea in 2009. Accessed July 2, 2012.
3. Korea Blood Cancer Association. Multiple myeloma treatment(In the middle of 2011). Accessed July 8, 2012.
4. The Korean Society of Hematology. Hematology. Seoul: E*PUBLIC;2006. p. 345–346.
5. Ferrell BR, Wisdom C, Wenzl C. Quality of life as an outcome variable in the management of cancer pain. Cancer. 1989; 63:11 suppl. 2321–2327.
6. Irvine D, Vincent L, Graydon JE, Bubela N, Thompson L. The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy: a comparison with the fatigue experienced by healthy individuals. Cancer Nurs. 1994; 17:367–378.
7. Byun HS, Kim GD. Impacts of fatigue, pain, anxiety, and depression on the quality of life in patients with breast cancer. Asian Oncol Nurs. 2012; 12:27–34.
8. Kim GD, Jang HJ. Effects of pain, sleep disturbance, and fatigue on the quality of life in patients with pancreatic cancer undergoing chemotherapy. Asian Oncol Nurs. 2012; 12:117–124.
9. Redeker NS, Lev EL, Ruggiero J. Insomnia, fatigue, anxiety, depression, and quality of life of cancer patients undergoing chemotherapy. Sch Inq Nurs Pract. 2000; 14:275–290.
10. Sezer O. Myeloma bone disease: recent advances in biology, diagnosis, and treatment. Oncologist. 2009; 14:276–283.
11. Green CR, Hart-Johnson T, Loeffler DR. Cancer-related chronic pain: examining quality of life in diverse cancer survivors. Cancer. 2011; 117:1994–2003.
12. Morgan MA, Small BJ, Donovan KA, Overcash J, McMillan S. Cancer patients with pain: the spouse/partner relationship and quality of life. Cancer Nurs. 2011; 34:13–23.
13. Hinz A, Krauss O, Hauss JP, Hockel M, Kortmann RD, Stolzenburg JU, et al. Anxiety and depression in cancer patients compared with the general population. Eur J Cancer Care (Engl). 2010; 19:522–529.
14. Lee EO, Eom A, Song R, Chae YR, Paul L. Factors influencing quality of life in patients with gastrointestinal neoplasms. J Korean Acad Nurs. 2008; 38:649–655.
15. Han EK. A study on symptom experience and quality of life of patients undergone hematopoietic stem cell transplantation [master's thesis]. Seoul: Chung-Ang Univ.;2012.
16. Booker R, Olson K, Pilarski LM, Noon JP, Bahlis NJ. The relationships among physiologic variables, quality of life, and fatigue in patients with multiple myeloma. Oncol Nurs Forum. 2009; 36:209–216.
17. Poulos AR, Gertz MA, Pankratz VS, Post-White J. Pain, mood disturbance, and quality of life in patients with multiple myeloma. Oncol Nurs Forum. 2001; 28:1163–1171.
18. Functional Assessment of Chronic Illness Therapy. FACIT-Fatigue scale-Korean version. Accessed July 2, 2012.
19. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983; 67:361–370.
20. Oh SM, Min KJ, Park DB. A study on the standardization of the hospital anxiety and deperession scale for Koreans. J Korean Neuropsychiatr Assoc. 1999; 38:289–296.
21. European Organization for Research and Treatment of Cancer. EORTC QLQ-C30 Korean version. Accessed July 2, 2012.
22. Jeong JY, So HS, Hong JE, Chae MJ, Han G. Related factors to quality of life among hospitalized cancer patients undergoing chemotherapy. Asian Oncol Nurs. 2012; 12:84–91.
23. Kim JH, Choi KS, Kim TW, Hong YS. Quality of life in colorectal cancer patients with chemotherapy-induced peripheral neuropathy. J Korean Oncol Nurs. 2011; 11:254–262.
24. Kim GD, Kim KH. Symptom cluster and quality of life in patients with breast cancer undergoing chemotherapy. Korean J Adult Nurs. 2011; 23:434–445.
25. Kim YS, Tae YS. The influencing factors on quality of life among breast cancer survivors. J Korean Oncol Nurs. 2011; 11:221–228.
26. Penttinen HM, Saarto T, Kellokumpu-Lehtinen P, Blomqvist C, Huovinen R, Kautiainen H, et al. Quality of life and physical performance and activity of breast cancer patient after adjuvant treatments. Psychooncology. 2011; 20:1211–1220.
27. Robinson DW Jr, Eisenberg DF, Cella D, Zhao N, DeBoer C, DeWitte M. The prognostic significance of patient-reported outcomes in pancreatic cancer cachexia. J Support Oncol. 2008; 6:283–290.
28. So WK, Marsh G, Ling WM, Leung FY, Lo JC, Yeung M, et al. The symptom cluster of fatigue, pain, anxiety, and depression and the quality of life of women receiving treatment for breast cancer: a multicenter study. Oncol Nurs Forum. 2009; 35:E205–E214.
29. Wi ES, Yong J. Distress, depression, anxiety, and spiritual needs of patients with stomach cancer. Asian Oncol Nurs. 2012; 12:314–322.
30. Meisel JL, Domchek SM, Vonderheide RH, Giobbie-Hurder A, Lin NU, Winer EP, et al. Quality of life in long-term survivors of metastatic breast cancer. Clin Breast Cancer. 2012; 12:119–126.
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