Korean J Med.  2014 Dec;87(6):698-704. 10.3904/kjm.2014.87.6.698.

Clinical Outcomes between Living Related and Living Unrelated Kidney Transplantation in ABO-Incompatible Kidney Transplant Recipients

• Park W
• Han S
• Hwang E
• Park S
• Park U
• Kim H
• Cho W

• KMID: 2269365
• DOI: http://doi.org/10.3904/kjm.2014.87.6.698

Abstract

BACKGROUND/AIMS
Kidney transplantation (KT) is the best treatment for end-stage renal disease patients. Although previous studies have demonstrated that the clinical outcome following living related (LR) KT is better than that following unrelated (LUR) KT in ABO-compatible KT recipients, recent studies showed no differences in clinical outcomes between the two treatments. In this study, we compared the clinical outcomes of LR and LUR KT in ABO-incompatible KT recipients.
METHODS
From January 2011 to August 2013, 19 cases of ABO-incompatible KT were analyzed retrospectively. Eight kidneys (7 cases of parent-offspring and 1 case of siblings, Group 1) were donated from living-related donors and 11 (all spousal donors, Group 2) from living-unrelated donors. We investigated patient survival, graft survival, acute rejection, graft function, and complications.
RESULTS
On Kaplan-Meier analysis, patient and graft survival during follow-up were 87.5% and 87.5% in Group 1; both were 100% in Group 2. Acute rejection, graft function, and medical and surgical complications were not significantly different between the two groups.
CONCLUSIONS
The short-term clinical outcomes between LR and LUR KT in ABO-incompatible KT recipients were equivalent. Most domestic cases of LUR KT are from spousal donors and the spousal donor will be a major donor in ABO-incompatible KT patients.

Keyword

Kidney transplantation; Living-unrelated; ABO-incompatible

MeSH Terms

Follow-Up Studies
Graft Rejection
Graft Survival
Humans
Kaplan-Meier Estimate
Kidney Failure, Chronic
Kidney Transplantation*
Kidney*
Retrospective Studies
Siblings
Tissue Donors
Transplantation*