Korean J Med.  2014 Dec;87(6):665-674. 10.3904/kjm.2014.87.6.665.

Severe Cutaneous Adverse Reaction

• Yang MS
• Jung JW
• Kang HR

• KMID: 2269361
• DOI: http://doi.org/10.3904/kjm.2014.87.6.665

Abstract

Severe adverse cutaneous reactions (SCARs) include Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). Although recent advances in pharmacogenomics have revealed the association between specific human leukocyte antigens (HLAs) and certain drug-induced SCARs, such associations were found in a limited number of drug-associated SCARs and are not sufficient to explain many other drug-related SCARs. After introducing research on the HLA-restricted T cell response, the role of the T cell receptor in drug binding was emphasized and a new concept called "pharmacological interactions of drug with immune receptors" has been conceptualized over recent decades. Currently, many international and domestic collaborative consortia have been formed and should enable the phenotypic standardization of SCARs at the earliest practicable time to provide valuable insights into its pathogenesis and to find an ideal method to prevent patients from developing SCARs.

Keyword

Stevens Johnson syndrome, toxic epidermal necrolysis; Drug hypersensitivity syndrome

MeSH Terms

Cicatrix
Drug Hypersensitivity Syndrome
HLA Antigens
Humans
Pharmacogenetics
Receptors, Antigen, T-Cell
Stevens-Johnson Syndrome
HLA Antigens
Receptors, Antigen, T-Cell