Korean J Community Nutr.  2011 Dec;16(6):762-770. 10.5720/kjcn.2011.16.6.762.

Association of Plasma Osteoprotegerin with Adiponectin and Difference according to Obesity in Men with Metabolic Syndrome

• Na W
• Sohn C

• KMID: 2267368
• DOI: http://doi.org/10.5720/kjcn.2011.16.6.762

Abstract

Osteoprotegerin (OPG) plays a core role in bone reformation by antagonizing the effect of receptor activator of nuclear factor kappa-B ligand (RANKL), and mediates vascular calcification in cardiovascular disease patients. Thus, we aimed to examine the relationship between serum OPG levels and cardiovascular factors and inflammatory markers in metabolic syndrome patients (MS). This cross-sectional study included 96 men who visited the diet clinic between May and July 2011. Patients were classified into 2 groups based on NCEP-ATP guidelines: normal and with MS (n = 50 and 46, respectively). Physical measurements, biochemical assay were measured. Serum OPG and IL-6, diponectin and hs-CRP were assessed. MS were aged 50.02 +/- 10.85 years, and normal patients 52.07 +/- 9.56 years, with no significant differences. Significant differences were not observed in BMI between the 2 groups. Moreover, significant differences were not observed in serum OPG, however, the serum OPG level (4.41 +/- 1.86 pmol/L) differed significantly between an overweight MS (BMI > 25) and normal patients. OPG was correlated to age (r = 0.410, p = 0.000), HDL-cholesterol (r = 0.209, p = 0.015), and log adiponectin (r = 0.175, p = 0.042). Multiple regression analyses using the enter method showed that age (beta = 0.412, p = 0.000) and BMI (beta = 0.265, p = 0.000) considerably affected OPG. In conclusion, out study showed that serum OPG levels are correlated with cardiovascular risk factors, such as BMI, HDL-cholesterol and adiponectin in MS and adiponectin, suggesting that serum OPG has potential as a cardiovascular disease indicator and predictor.

Keyword

osteoprotegerin; cardiovascular disease risk factors; inflammatory markers; adiponectin

MeSH Terms

Adiponectin
Aged
Cardiovascular Diseases
Cross-Sectional Studies
Diet
Humans
Interleukin-6
Male
Obesity
Osteoprotegerin
Overweight
Plasma
Risk Factors
Vascular Calcification
Adiponectin
Interleukin-6
Osteoprotegerin

Figure

• 

  Fig. 1 Difference of OPG levels between MS group and control group according to body mass index.

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