Ann Pediatr Endocrinol Metab.  2013 Dec;18(4):179-182. 10.6065/apem.2013.18.4.179.

Changes of antithroglobulin antibody in children with congenital hypothyroidism

• Cho EM
• Kim UH
• Choi BH
• Ko CW

• KMID: 2266352
• DOI: http://doi.org/10.6065/apem.2013.18.4.179

Abstract

PURPOSE
It has been reported that antithroglobulin (anti-TG) antibody is increased in the sera of both children with transient congenital hypothyroidism and their mothers. And transplacental transport of thyroid autoantibody was proposed as the pathogenesis of transient congenital hypothyroidism. However this is not known in nontransient congenital hypothyroidism. This study was done to see changes of anti-TG antibody in children with nontransient congenital hypothyroidism.
METHODS
Study patients consisted of 60 patients diagnosed as congenital hypothyroidism in the Department of Pediatrics, Kyungpook National University Children's Hospital, Daegu, Republic of Korea between January 2010 and March 2013. Healthy control were 45 children showing normal thyroid function. Anti-TG antibody and various laboratory tests were analyzed retrospectively, and compared in both children with congenital hypothyroidism and controls.
RESULTS
Anti-TG antibody was significantly higher in children with congenital hypothyroidism compared to healthy controls, 119.4+/-34.7 U/mL versus 80.6+/-19.6 U/mL, respectively (P<0.001). There was no significant difference of anti-TG antibody in gender and age.
CONCLUSION
We observed a significant increase of anti-TG antibody in children with nontransient congenital hypothyroidism compared to healthy controls. Further study focusing pathogenetic role of anti-TG antibody in nontransient congenital hypothyroidism is necessary. Furthermore, the clinical significance in the course of congenital hypothyroidism need to be known.

Keyword

Congenital hypothyroidism; Autoantibodies; Anti-thyroglobulin antibody

MeSH Terms

Autoantibodies
Child*
Congenital Hypothyroidism*
Daegu
Humans
Mothers
Pediatrics
Republic of Korea
Retrospective Studies
Thyroid Gland
Autoantibodies

Figure

• 

  Fig. 1 Distributions of antithyroglobulin antibody (anti-TG Ab) in children with congenital hypothyroidism and controls. Translucent area indicates range of anti-TG Ab titer in controls. The cause of congenital hypothyroidism in patients with 3 highest titers was thyroid agenesis (*).

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