Ann Dermatol.  2012 Nov;24(4):406-412. 10.5021/ad.2012.24.4.406.

Effect of the Pruritus on the Quality of Life: A Preliminary Study

• Erturk IE
• Arican O
• Omurlu IK
• Sut N

• KMID: 2266034
• DOI: http://doi.org/10.5021/ad.2012.24.4.406

Abstract

BACKGROUND
Pruritus affects the quality of life (QoL) in the patients. However, little is known of the impacts of itching on the QoL in the literature.
OBJECTIVE
In this study, a questionnaire eliciting specific responses about pruritus was used to determine the effect of itching and its severity on QoL in chronic pruritic patients.
METHODS
One hundred ten adult patients with chronic pruritus were surveyed. Once itch severity had been self-reported by patients, together with Skindex-29, they have been given the 18-item Pruritus-related Life Quality Index (PLQI) questionnaire, which was used to generated the new index.
RESULTS
Significant correlations have been found between the pruritus severity score of participants and their total Skindex-29 (p<0.001) with its function, emotion and symptom subscale scores (p<0.001 for each). Also, significant correlations were evident between total PLQI (p<0.001) and its psychosocial negativities, difficulties in everyday activities and social live subscale scores (p<0.001 for each). In particular, the emotion subscale of Skindex-29 (p=0.02) and psychosocial negativity subscale of PLQI (p=0.02) were significantly high in psychopathologic patients. A highly positive statistical correlation between Skindex-29 and PLQI scales was evident (r=0.845, p<0.001). For reliability, Cronbach's coefficient a coefficients were 0.931 for the Skindex-29 scale and 0.918 for the PLQI scale.
CONCLUSION
The results demonstrate that chronic pruritus appreciably reduces the QoL. PLQI could be used in the development of new questionnaires for determining the QoL of patients with chronic itch.

Keyword

Pruritus; Quality of life; Questionnaires

MeSH Terms

Adult
Humans
Pruritus
Quality of Life
Weights and Measures
Surveys and Questionnaires

Figure

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  Fig. 1 Spearman rank correlation coefficients of Skindex-29 score with Pruritus-related Life Quality Index (PLQI) score.

Reference

1. Grundmann S, Ständer S. Chronic pruritus: clinics and treatment. Ann Dermatol. 2011. 23:1–11.

2. Arican O. Mechanisms and treatment options of pruritus associated with systemic diseases: a review. Turkiye Klinikleri J Med Sci. 2004. 24:664–671.

3. Arican O. Pathophysiology, clinical presentation and management of pruritus. Turkderm. 2005. 39:88–97.

4. Dogramaci AC, Serarslan G. The prevalence of pruritus in Mustafa Kemal University Dermatology outpatient clinic during July 2008. Trakya Univ Tip Fak Derg. 2009. 26:137–140.

5. van Os-Medendorp H, Eland-de Kok PC, Grypdonck M, Bruijnzeel-Koomen CA, Ros WJ. Prevalence and predictors of psychosocial morbidity in patients with chronic pruritic skin diseases. J Eur Acad Dermatol Venereol. 2006. 20:810–817.

6. Bilac C, Ermertcan AT, Bilac DB, Deveci A, Horasan GD. The relationship between symptoms and patient characteristics among psoriasis patients. Indian J Dermatol Venereol Leprol. 2009. 75:551.

7. Gurel MS, Yanik M, Simsek Z, Kati M, Karaman A. Quality of life instrument for Turkish people with skin diseases. Int J Dermatol. 2005. 44:933–938.

8. Lange S, Zschocke I, Seidenglanz K, Schiffler A, Zollinger A, Amon U, et al. Predictors of the quality of life in patients with atopic dermatitis. Dermatol Psychosom. 2000. 1:66–70.

9. Gupta MA, Gupta AK, Schork NJ, Ellis CN. Depression modulates pruritus perception: a study of pruritus in psoriasis, atopic dermatitis, and chronic idiopathic urticaria. Psychosom Med. 1994. 56:36–40.

10. Duque MI, Yosipovitch G, Chan YH, Smith R, Levy P. Itch, pain, and burning sensation are common symptoms in mild to moderate chronic venous insufficiency with an impact on quality of life. J Am Acad Dermatol. 2005. 53:504–508.

11. Arican O. Measuring of quality of life in dermatological patients. Turkiye Klinikleri J Dermatol (Special Topics). 2009. 2:107–114.

12. Tessari G, Dalle Vedove C, Loschiavo C, Tessitore N, Rugiu C, Lupo A, et al. The impact of pruritus on the quality of life of patients undergoing dialysis: a single centre cohort study. J Nephrol. 2009. 22:241–248.

13. Tol H, Atalay H, Guney I, Gokbel H, Altintepe L, Buyukbas S, et al. The effect of Gabapentin therapy on pruritus, quality of life, depression and sleep quality in pruritic hemodialysis patients. Trakya Univ Tip Fak Derg. 2010. 27:1–5.

14. Desai NS, Poindexter GB, Monthrope YM, Bendeck SE, Swerlick RA, Chen SC. A pilot quality-of-life instrument for pruritus. J Am Acad Dermatol. 2008. 59:234–244.

15. Aksu AE, Urer MS, Sabuncu I, Saracoglu ZN, Chren MM. Turkish version of Skindex-29. Int J Dermatol. 2007. 46:350–355.

16. Kaufmann R, Bieber T, Helgesen AL, Andersen BL, Luger T, Poulin Y, et al. Multicentre investigator group. Onset of pruritus relief with pimecrolimus cream 1% in adult patients with atopic dermatitis: a randomized trial. Allergy. 2006. 61:375–381.

17. Gieler U, Niemeier V, Brosig B, Kupfer J. Psychosomatic aspects of pruritus. Dermatol Psychosom. 2002. 3:6–13.

18. Amatya B, Nordlind K. Focus groups in Swedish psoriatic patients with pruritus. J Dermatol. 2008. 35:1–5.

19. Zachariae R, Zachariae CO, Lei U, Pedersen AF. Affective and sensory dimensions of pruritus severity: associations with psychological symptoms and quality of life in psoriasis patients. Acta Derm Venereol. 2008. 88:121–127.

20. Weisshaar E, Dalgard F. Epidemiology of itch: adding to the burden of skin morbidity. Acta Derm Venereol. 2009. 89:339–350.

21. Reich A, Szepietowski JC, Wisnicka B, Pacan P. Does stress influence itching in psoriatic patients? Dermatol Psychosom. 2003. 4:151–155.

22. Yalçin B, Tamer E, Toy GG, Oztaş P, Hayran M, Alli N. The prevalence of skin diseases in the elderly: analysis of 4099 geriatric patients. Int J Dermatol. 2006. 45:672–676.

23. Schneider G, Driesch G, Heuft G, Evers S, Luger TA, Ständer S. Psychosomatic cofactors and psychiatric comorbidity in patients with chronic itch. Clin Exp Dermatol. 2006. 31:762–767.

24. Sheehan-Dare RA, Henderson MJ, Cotterill JA. Anxiety and depression in patients with chronic urticaria and generalized pruritus. Br J Dermatol. 1990. 123:769–774.

25. Radmanesh M, Shafiei S. Underlying psychopathologies of psychogenic pruritic disorders. Dermatol Psychosom. 2001. 2:130–133.

26. Chrostowska-Plak D, Salomon J, Reich A, Szepietowski JC. Clinical aspects of itch in adult atopic dermatitis patients. Acta Derm Venereol. 2009. 89:379–383.

27. Reich A, Szepietowski JC, Wisnicka B, Pacan P. Does stress influence itching in psoriatic patients? Dermatol Psychosom. 2003. 4:151–155.

28. Holm EA, Wulf HC, Stegmann H, Jemec GB. Life quality assessment among patients with atopic eczema. Br J Dermatol. 2006. 154:719–725.

29. Wittkowski A, Richards HL, Griffiths CE, Main CJ. The impact of psychological and clinical factors on quality of life in individuals with atopic dermatitis. J Psychosom Res. 2004. 57:195–200.

30. Weisshaar E, Apfelbacher C, Jäger G, Zimmermann E, Bruckner T, Diepgen TL, et al. Pruritus as a leading symptom: clinical characteristics and quality of life in German and Ugandan patients. Br J Dermatol. 2006. 155:957–964.

31. Baiardini I, Pasquali M, Braido F, Fumagalli F, Guerra L, Compalati E, et al. A new tool to evaluate the impact of chronic urticaria on quality of life: chronic urticaria quality of life questionnaire (CU-QoL). Allergy. 2005. 60:1073–1078.