Ann Dermatol.  2013 Feb;25(1):84-87. 10.5021/ad.2013.25.1.84.

An Unusual Association between Sweet's Syndrome and Metastatic Papillary Follicular Thyroid Carcinoma

  • 1Division of Allergy and Immunology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
  • 2Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
  • 3Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.


Sweet's syndrome (SS), or acute febrile neutrophilic dermatosis, is marked by fever, leukocytosis, and painful erythematous papules/plaques resulting from neutrophil migration and accumulation in the dermis. This condition has been associated with underlying hematologic as well as solid malignancies. We describe a unique case of SS in a patient with metastatic papillary follicular thyroid carcinoma and group A streptococcal pharyngitis. The distribution of the patient's SS rash was similar to the rash of neutrophilic dermatosis (pustular vasculitis) of the dorsal hands.


Carcinoma; Skin disease; Sweet syndrome; Thyroid gland

MeSH Terms

Adenocarcinoma, Follicular
Immune System Diseases
Leukocyte Disorders
Skin Diseases
Sweet Syndrome
Thyroid Gland
Immune System Diseases
Leukocyte Disorders


  • Fig. 1 Skin findings in our patient.

  • Fig. 2 (A) Inflammatory infiltrate around the vessels (H&E, ×20). (B) Dermal inflammatory infiltrate (mixed populaion of cells) with neutrophils (H&E, ×400). (C) Inflammatory infiltrate within around vessel wall (H&E, ×200). (D) Vessel wall with Inflammatory infiltrate (including neutrophils) and nuclear debris from neutrophils in and around the vessels (H&E, ×400).


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