Ann Dermatol.  2013 Feb;25(1):84-87. 10.5021/ad.2013.25.1.84.

An Unusual Association between Sweet's Syndrome and Metastatic Papillary Follicular Thyroid Carcinoma

Affiliations
  • 1Division of Allergy and Immunology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA. sjariwal@montefiore.org
  • 2Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
  • 3Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, USA.

Abstract

Sweet's syndrome (SS), or acute febrile neutrophilic dermatosis, is marked by fever, leukocytosis, and painful erythematous papules/plaques resulting from neutrophil migration and accumulation in the dermis. This condition has been associated with underlying hematologic as well as solid malignancies. We describe a unique case of SS in a patient with metastatic papillary follicular thyroid carcinoma and group A streptococcal pharyngitis. The distribution of the patient's SS rash was similar to the rash of neutrophilic dermatosis (pustular vasculitis) of the dorsal hands.

Keyword

Carcinoma; Skin disease; Sweet syndrome; Thyroid gland

MeSH Terms

Adenocarcinoma, Follicular
Dermis
Exanthema
Fever
Hand
Humans
Immune System Diseases
Leukocyte Disorders
Leukocytosis
Neutrophils
Pharyngitis
Skin Diseases
Sweet Syndrome
Thyroid Gland
Immune System Diseases
Leukocyte Disorders

Figure

  • Fig. 1 Skin findings in our patient.

  • Fig. 2 (A) Inflammatory infiltrate around the vessels (H&E, ×20). (B) Dermal inflammatory infiltrate (mixed populaion of cells) with neutrophils (H&E, ×400). (C) Inflammatory infiltrate within around vessel wall (H&E, ×200). (D) Vessel wall with Inflammatory infiltrate (including neutrophils) and nuclear debris from neutrophils in and around the vessels (H&E, ×400).


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