Korean J Cytopathol.  1996 Dec;7(2):134-137.

Demonstration of TCM-9 Monoclonal Antibody in Follicular Neoplasm of Thyroid

• Kim YJ
• Shim JW
• Ahn HK
• Park YE

Abstract

Monoclonal antibody(TCM-9) against human thyroid cancers have been studied by screening with human thyroid cancers, normal and benign thyroid tissue, and normal human serum protein. A monoclonal antibody(TCM-9) that is known to have strong specificity for human thyroid cancer but not for Graves' disease, adenoma or normal thyroid does not bind to native or mature human thyroglobulin(Tg). We used to TCM-9 antibody by immunohistochemical staining on 5 follicular cancer, 2 follicular adenoma, 1 follicular neoplasm with suspicious invasion, 2 papillary cancer to ascer- tain being of help in differentiation between follicular carcinoma and adenoma. Reactivity of TCM-9 was observed in follicular carcinoma and papillary carcinoma but not observed in follicular adenoma. Thus TCM-9 is a novel monoclonal antibody against the thyroid cancer.

Keyword

TCM-9; Papillary cancer; Follicular cancer; Follicular adenoma

MeSH Terms

Adenoma
Carcinoma, Papillary
Graves Disease
Humans
Mass Screening
Sensitivity and Specificity
Thyroid Gland*
Thyroid Neoplasms