Ann Dermatol.  2013 Aug;25(3):378-379. 10.5021/ad.2013.25.3.378.

Longitudinal Melanonychia on the Lateral Side of the Nail: A Sign of Bowen Disease Associated with Human Papillomavirus

Affiliations
  • 1Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. dylee@skku.edu
  • 2Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

No abstract available.


MeSH Terms

Bowen's Disease
Humans

Figure

  • Fig. 1 Dark brown colored longitudinal melanonychia on the left thumbnail.

  • Fig. 2 (A) Many atypical dyskeratotic keratinocytes are observed in the epidermis (H&E, ×200). (B) Melanocytic hyperplasia is shown via HMB 45 immunohistochemistry (HMB-45, ×200). (C) Human papillomavirus is found in the horny layers through immunohistochemistry (HPV, ×200).


Reference

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2. Baran R, Simon C. Longitudinal melanonychia: a symptom of Bowen's disease. J Am Acad Dermatol. 1988; 18:1359–1360.
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3. Sass U, André J, Stene JJ, Noel JC. Longitudinal melanonychia revealing an intraepidermal carcinoma of the nail apparatus: detection of integrated HPV-16 DNA. J Am Acad Dermatol. 1998; 39:490–493.
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4. Lambiase MC, Gardner TL, Altman CE, Albertini JG. Bowen disease of the nail bed presenting as longitudinal melanonychia: detection of human papillomavirus type 56 DNA. Cutis. 2003; 72:305–309.
5. Shimizu A, Tamura A, Abe M, Motegi S, Nagai Y, Ishikawa O, et al. Detection of human papillomavirus type 56 in Bowen's disease involving the nail matrix. Br J Dermatol. 2008; 158:1273–1279.
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