Ann Dermatol.  2014 Aug;26(4):510-513. 10.5021/ad.2014.26.4.510.

Myxoid Cellular Neurothekeoma: A New Entity of S100-Negative, CD68-Positive Myxoid Neurothekeoma

• Yun SJ
• Park HS
• Lee JB
• Kim SJ
• Lee SC
• Won YH

• KMID: 2265595
• DOI: http://doi.org/10.5021/ad.2014.26.4.510

Abstract

Neurothekeoma is a rare cutaneous neoplasm, occurring as a cutaneous papule or nodule on the face, shoulders, and upper extremities. Neurothekeoma has been subclassified as either the myxoid, cellular, or mixed type, depending on the amount of myxoid matrix and on immunohistochemical analysis. We observed a clinical case with conflicting histopathological and immunohistochemical findings. In this case, microscopic examination showed the typical presentation of myxoid neurothekeoma; however, immunohistochemical staining was negative for S100 protein and positive for CD68, which is the characteristic pattern of cellular neurothekeoma. We report a very rare form of myxoid cellular neurothekeoma of the face in a young woman.

Keyword

CD68; Neurothekeoma; S100 protein

MeSH Terms

Female
Humans
Neurothekeoma*
Shoulder
Upper Extremity

Figure

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  Fig. 1 (A) A solitary erythematous, 0.7-×0.6-cm, telangiectatic nodule on the left eyebrow. (B) The nodule has a smooth and shiny surface with some telangiectasia.

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  Fig. 2 Histopathological findings. (A) The tumor is in the dermis and lobulated, not encapsulated (H&E, ×20). (B~D) The tumor cells were composed of stellate and spindle-shaped cells within an abundant myxoid stroma (H&E; B: ×100, C: ×200, D: ×400).

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  Fig. 3 Immunohistochemical findings. (A) The amount of myxoid stroma was >50% (alcian blue, ×40). (B, C) The tumor cells were positive for CD68 and vimentin (B: CD68, ×100; C: vimentin, ×100). The tumor cells were negative for S100 protein (D, ×100), CD57 (E, ×100), and glial fibrillary acidic protein (F, ×100).

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