Ann Dermatol.  2010 May;22(2):219-222. 10.5021/ad.2010.22.2.219.

A Case of Lymphomatoid Keratosis

Affiliations
  • 1Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. yymmpark6301@ hotmail.com
  • 2Department of Pathology, College of Medicine, Chung-Ang University, Seoul, Korea.

Abstract

Lymphomatoid keratosis (LK) is considered to be a rare variant of cutaneous lymphoid hyperplasia, with epidermotropism. We herein report a case of LK which developed on the abdomen of an elderly Korean woman. A 60-year-old woman presented with a 10-year history of a pruritic, solitary, brown to black plaque on the abdomen. Histopathologically, the specimen showed hyperkeratosis, parakeratosis, acanthosis and Pautrier's micro-abscess in the epidermis, and a lichenoid infiltration of lymphocytes in the dermis, which expressed both B cell and T cell lineage on the immune-histochemical staining. Based on these clinical and histopathological findings, our case was diagnosed as LK. To our knowledge, this is the first case report of LK in the Korean dermatologic literature.

Keyword

Cutaneous lymphoid hyperplasia; Epidermotropism; Lymphomatoid keratosis

MeSH Terms

Abdomen
Aged
Cell Lineage
Dermis
Epidermis
Female
Humans
Hyperplasia
Keratosis
Lymphocytes
Middle Aged
Parakeratosis

Figure

  • Fig. 1 Pruritic, solitary, well-demarcated, brown to black plaque, 3.8×1.2 cm in size, on the abdomen.

  • Fig. 2 Dermoscopic finding of the lesion showed a globular pattern with brown dots and globules at the periphery.

  • Fig. 3 Hyperkeratosis, parakeratosis, acanthosis, papillomatosis and hypergranulosis in the epidermis which was consistent with seborrheic keratosis (H&E, ×40).

  • Fig. 4 (A, B) Epidermal hyperplasia and epidermotropism in the epidermis and formation of lymphoid follicle and lichenoid infiltration of lymphocytes in the reticular dermis (H&E stain, ×40, ×100). (C) Epidermotropism with Pautrier's microabscess in the epidermis (H&E stain, ×400). (D) Lichenoid infiltration of lymphocytes in the reticular dermis (H&E stain, ×400).

  • Fig. 5 Immunohistochemical study for CD3 (A), CD4 (B), CD8 (C), CD20 (D), showed positive staining with lymphocytes (H&E, ×400).


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