Ann Dermatol.  2010 May;22(2):196-198. 10.5021/ad.2010.22.2.196.

A Case of Kikuchi's Disease Presenting with Unique Facial Involvement

• Heo YS
• Son SB
• Kim JE
• Oh CH
• Song HJ

• KMID: 2265393
• DOI: http://doi.org/10.5021/ad.2010.22.2.196

Abstract

Kikuchi's disease (KD), or histiocytic necrotizing lymphadenitis, is a rare, self-limited lymphadenopathy, typically in young women, that usually remits spontaneously and does not recur. KD is clinically characterized by cervical lymphadenopathy and a high fever. Extranodal involvement (skin, arthritis, meningitis) rarely occurs. When KD is involved in a skin lesion, it presents with various shapes, but rarely manifests with symmetrically distributed, erythematous, firm nodules only on the face. In this report, we describe a patient with KD and unique skin manifestations.

Keyword

Cutaneous involvement; Histiocytic necrotizing lymphadenitis; Kikuchi's disease

MeSH Terms

Arthritis
Female
Fever
Histiocytic Necrotizing Lymphadenitis
Humans
Lymphatic Diseases
Skin
Skin Manifestations

Figure

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  Fig. 1 Symmetrically distributed erythematous firm nodules measuring 8 mm in diameter are seen on both cheeks.

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  Fig. 2 (A) Patchy infiltration of mononuclear cells around skin appendages and blood vessels (H&E, ×40). (B) Infiltrating cells are composed of large, atypical lymphocytes, histiocytes with crescent-shaped nuclei, and many apoptotic cells (H&E, ×200). (C) The histiocytic cells are positive for CD68 (×100).

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