Ann Dermatol.  2010 Aug;22(3):346-348. 10.5021/ad.2010.22.3.346.

Two Cases of Idiopathic Localized Involutional Lipoatrophy

• Lee YB
• Kim JE
• Park HJ
• Cho BK

• KMID: 2265374
• DOI: http://doi.org/10.5021/ad.2010.22.3.346

Abstract

Localized involutional lipoatrophy (LIL) is a rare distinctive idiopathic form of localized lipoatrophy. The characteristic features in histopathology of LIL are diminutive fat lobules composed of small adipocyte resembling fetal fat tissue. LIL is not a well-known disorder, there have been only a few reports on LIL in the English literature. We herein report 2 cases of LIL and review the previously published cases.

Keyword

Idiopathic; Involutional; Lipoatrophy; Localized

MeSH Terms

Adipocytes

Figure

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  Fig. 1 (A) Well-demarcated, 3×4 cm, hypopigmented, atrophic, depressed lesion on the lower back was seen on the lower back of the first patient (inlet, lateral aspect view). (B) Well-demarcated, 3×4 cm, hypopigmented, atrophic, pinkish, depressed lesion was seen on the upper back of the second patient (inlet, lateral aspect view).

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  Fig. 2 (A) Histopathologic examination of a sample taken from the first patient showed atrophic epidermis and prominent collagen bundles in the dermis without inflammation (H&E stain, ×40). (B) A view at higher magnification revealed that the homogenized collagen bundles entrapped characteristic diminutive fat lobules resembling fetal adipose tissue (H&E stain, ×100). (C) The biopsy specimen from the second patient showed atrophic epidermis and increased collagen bundles in the dermis (H&E stain, ×40). (D) Diminutive fat lobules were seen in the subcutaneous layer (H&E stain, ×100). (E) A view at higher magnification revealed that the immature adipocytes were variable in size and embedded in well-vascularized stroma (H&E stain, ×400).

Reference

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