Ann Dermatol.  2010 Aug;22(3):312-315. 10.5021/ad.2010.22.3.312.

A Case of Hydroa Vacciniforme

• Park HY
• Park JH
• Lee KT
• Lee DY
• Lee JH
• Lee ES
• Yang JM

• KMID: 2265365
• DOI: http://doi.org/10.5021/ad.2010.22.3.312

Abstract

Hydroa vacciniforme (HV) is a rare and chronic pediatric disorder that is characterized by photosensitivity and recurrent vesicles that heal with vacciniforme scarring. The pathogenesis of HV is unknown; no chromosome abnormality has been identified. HV patients have no abnormal laboratory results, so the diagnosis of HV is based on identifying the associated histological findings in a biopsy specimen and using repetitive ultraviolet phototesting to reproduce the characteristic vesicles on a patient's skin. Herein, we present a case of HV in a 7-year-old female who was diagnosed with HV according to histopathology and ultraviolet phototesting.

Keyword

Hydroa vacciniforme; Photodermatosis; Phototest

MeSH Terms

Biopsy
Child
Chromosome Aberrations
Cicatrix
Female
Humans
Hydroa Vacciniforme
Skin

Figure

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  Fig. 1 Erythematous, pitted and atrophic scars with crusting on the nose and cheek.

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  Fig. 2 Diffuse, hypopigmented and umbilicated scars on the dorsa of the hands.

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  Fig. 3 Histopathology from the erythematous vesicles on the patient's face showed epidermal necrosis, intraepidermal vesicles with spongiosis and a superficial perivascular lymphocytic infiltration (H&E stain, ×100).

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  Fig. 4 (A) There were no infiltrating mononuclear cells that expressed Epstein-Barr virus-determined nuclear antigens (EBNA) in the lesional skin biopsy specimen (×100). (B) There were no infiltrating mononuclear cells that expressed Epstein-Barr virus-latent membrane proteins (LMP) in the lesional skin biopsy specimen (×100).

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  Fig. 5 The duplicate ultraviolet-A-irradiated sites demonstrate vesiculation.

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