Ann Dermatol.  2015 Feb;27(1):15-20. 10.5021/ad.2015.27.1.15.

Retrospective Clinical Trial of Fusidic Acid versus Petrolatum in the Postprocedure Care of Clean Dermatologic Procedures

Affiliations
  • 1Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. sycho@snu.ac.kr
  • 2Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea.
  • 3Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.

Abstract

BACKGROUND
Clean dermatologic procedures create wounds with a low risk of infection (usually up to 5%). Whether the use of topical antibiotics is advocated, with regard to its efficacy and safety issues such as antibiotic resistance and sensitizing potential, is controversial. Fusidic acid, a topical antibiotic against gram-positive bacteria, is a rare sensitizer and commonly used in postprocedure care in Korea.
OBJECTIVE
This is a retrospective study aimed at comparing the efficacy and safety between fusidic acid and petrolatum for the postprocedure care of clean dermatologic procedures.
METHODS
Patients were treated with either fusidic acid or petrolatum ointment, applied on the wound created during clean dermatologic procedures such as biopsy of the punch, incisional, excisional, and shave types. The efficacy, adverse events, and subjective level of satisfaction were retrieved from medical records.
RESULTS
A total of 414 patients with a total of 429 wounds were enrolled. The overall rate of adverse events was 0.9%, and the rates of adverse events in the fusidic acid group and the petrolatum group were 1.4% and 0.5%, respectively (p=0.370). There was no wound discharge, pain, tenderness, swelling, induration, or dehiscence in both groups. The patients' self-assessment of the wound was not significantly different between the two treatment groups.
CONCLUSION
Our findings support the hypothesis that the routine prophylactic use of topical antibiotics is not indicated for clean dermatologic procedures. We recommend the use of petrolatum in the postoperative care of clean dermatologic procedures because of its equivalent efficacy and superior safety profiles.

Keyword

Dermatologic surgical procedures; Fusidic acid; Infection; Petrolatum; Wound healing

MeSH Terms

Anti-Bacterial Agents
Biopsy
Dermatologic Surgical Procedures
Drug Resistance, Microbial
Fusidic Acid*
Gram-Positive Bacteria
Humans
Korea
Medical Records
Petrolatum*
Postoperative Care
Retrospective Studies*
Self-Assessment
Wound Healing
Wounds and Injuries
Anti-Bacterial Agents
Fusidic Acid
Petrolatum

Reference

1. Del Rosso JQ, Kim GK. Topical antibiotics: therapeutic value or ecologic mischief? Dermatol Ther. 2009; 22:398–406.
Article
2. Garner JS. CDC guideline for prevention of surgical wound infections, 1985. Supersedes guideline for prevention of surgical wound infections published in 1982. (Originally published in November 1985). Revised. Infect Control. 1986; 7:193–200.
3. Dixon AJ, Dixon MP, Askew DA, Wilkinson D. Prospective study of wound infections in dermatologic surgery in the absence of prophylactic antibiotics. Dermatol Surg. 2006; 32:819–826. discussion 826-827.
Article
4. Futoryan T, Grande D. Postoperative wound infection rates in dermatologic surgery. Dermatol Surg. 1995; 21:509–514.
Article
5. Cook JL, Perone JB. A prospective evaluation of the incidence of complications associated with Mohs micrographic surgery. Arch Dermatol. 2003; 139:143–152.
Article
6. Bencini PL, Galimberti M, Signorini M, Crosti C. Antibiotic prophylaxis of wound infections in skin surgery. Arch Dermatol. 1991; 127:1357–1360.
Article
7. Rogers HD, Desciak EB, Marcus RP, Wang S, MacKay-Wiggan J, Eliezri YD. Prospective study of wound infections in Mohs micrographic surgery using clean surgical technique in the absence of prophylactic antibiotics. J Am Acad Dermatol. 2010; 63:842–851.
Article
8. Maragh SL, Brown MD. Prospective evaluation of surgical site infection rate among patients with Mohs micrographic surgery without the use of prophylactic antibiotics. J Am Acad Dermatol. 2008; 59:275–278.
Article
9. McHugh SM, Collins CJ, Corrigan MA, Hill AD, Humphreys H. The role of topical antibiotics used as prophylaxis in surgical site infection prevention. J Antimicrob Chemother. 2011; 66:693–701.
Article
10. Heal CF, Buettner PG, Cruickshank R, Graham D, Browning S, Pendergast J, et al. Does single application of topical chloramphenicol to high risk sutured wounds reduce incidence of wound infection after minor surgery? Prospective randomised placebo controlled double blind trial. BMJ. 2009; 338:a2812.
Article
11. Dire DJ, Coppola M, Dwyer DA, Lorette JJ, Karr JL. Prospective evaluation of topical antibiotics for preventing infections in uncomplicated soft-tissue wounds repaired in the ED. Acad Emerg Med. 1995; 2:4–10.
Article
12. Dixon AJ, Dixon MP, Dixon JB. Randomized clinical trial of the effect of applying ointment to surgical wounds before occlusive dressing. Br J Surg. 2006; 93:937–943.
Article
13. Campbell RM, Perlis CS, Fisher E, Gloster HM Jr. Gentamicin ointment versus petrolatum for management of auricular wounds. Dermatol Surg. 2005; 31:664–669.
Article
14. Smack DP, Harrington AC, Dunn C, Howard RS, Szkutnik AJ, Krivda SJ, et al. Infection and allergy incidence in ambulatory surgery patients using white petrolatum vs bacitracin ointment. A randomized controlled trial. JAMA. 1996; 276:972–977.
Article
15. Del Rosso JQ, Leyden JJ. Status report on antibiotic resistance: implications for the dermatologist. Dermatol Clin. 2007; 25:127–132. v
Article
16. Gehrig KA, Warshaw EM. Allergic contact dermatitis to topical antibiotics: Epidemiology, responsible allergens, and management. J Am Acad Dermatol. 2008; 58:1–21.
Article
17. Warshaw EM, Belsito DV, Taylor JS, Sasseville D, DeKoven JG, Zirwas MJ, et al. North American Contact Dermatitis Group patch test results: 2009 to 2010. Dermatitis. 2013; 24:50–59.
18. Sheth VM, Weitzul S. Postoperative topical antimicrobial use. Dermatitis. 2008; 19:181–189.
Article
19. Taylor SC, Averyhart AN, Heath CR. Postprocedural woundhealing efficacy following removal of dermatosis papulosa nigra lesions in an African American population: a comparison of a skin protectant ointment and a topical antibiotic. J Am Acad Dermatol. 2011; 64:3 Suppl. S30–S35.
20. Draelos ZD, Rizer RL, Trookman NS. A comparison of postprocedural wound care treatments: do antibiotic-based ointments improve outcomes? J Am Acad Dermatol. 2011; 64:3 Suppl. S23–S29.
Article
21. Morris SD, Rycroft RJ, White IR, Wakelin SH, McFadden JP. Comparative frequency of patch test reactions to topical antibiotics. Br J Dermatol. 2002; 146:1047–1051.
Article
22. Eaglstein WH. Moist wound healing with occlusive dressings: a clinical focus. Dermatol Surg. 2001; 27:175–181.
Article
23. Levender MM, Davis SA, Kwatra SG, Williford PM, Feldman SR. Use of topical antibiotics as prophylaxis in clean dermatologic procedures. J Am Acad Dermatol. 2012; 66:445–451.
Article
24. Trookman NS, Rizer RL, Weber T. Treatment of minor wounds from dermatologic procedures: a comparison of three topical wound care ointments using a laser wound model. J Am Acad Dermatol. 2011; 64:3 Suppl. S8–S15.
25. Sachs B, Fischer-Barth W, Erdmann S, Merk HF, Seebeck J. Anaphylaxis and toxic epidermal necrolysis or Stevens-Johnson syndrome after nonmucosal topical drug application: fact or fiction? Allergy. 2007; 62:877–883.
Article
26. Tam CC, Elston DM. Allergic contact dermatitis caused by white petrolatum on damaged skin. Dermatitis. 2006; 17:201–203.
Article
27. Kang H, Choi J, Lee AY. Allergic contact dermatitis to white petrolatum. J Dermatol. 2004; 31:428–430.
Article
28. Mason BW, Howard AJ. Fusidic acid resistance in community isolates of methicillin susceptible Staphylococcus aureus and the use of topical fusidic acid: a retrospective case-control study. Int J Antimicrob Agents. 2004; 23:300–303.
Article
29. Sule O, Brown NM, Willocks LJ, Day J, Shankar S, Palmer CR, et al. Fusidic acid-resistant Staphylococcus aureus (FRSA) carriage in patients with atopic eczema and pattern of prior topical fusidic acid use. Int J Antimicrob Agents. 2007; 30:78–82.
Article
30. Schöfer H, Simonsen L. Fusidic acid in dermatology: an updated review. Eur J Dermatol. 2010; 20:6–15.
31. Shah M, Mohanraj M. High levels of fusidic acid-resistant Staphylococcus aureus in dermatology patients. Br J Dermatol. 2003; 148:1018–1020.
Article
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