Korean J Med.
2011 Jul;81(1):102-106.
A Case of Birt-Hogg-Dube Syndrome Diagnosed by a Folliculin Gene Mutation
- Affiliations
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- 1Department of Internal Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea. ckpaul@catholic.ac.kr
- 2Department of Radiology, The Catholic University of Korea School of Medicine, Seoul, Korea.
- 3Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Abstract
- Birt-Hogg-Dube (BHD) syndrome is a rare, autosomal-dominant disorder that is caused by germ-line mutations in the folliculin gene. Clinically, BHD syndrome is characterized by cutaneous follicle tumors, pulmonary cysts, spontaneous pneumothorax, and an increased risk of renal cancer. A 65-year-old woman was admitted to Seoul St. Mary's Hospital to treat pneumonia, and we found that she had experienced recurrent spontaneous pneumothorax and had bilateral multiple pulmonary cysts with no history of smoking. Mutation analysis of the folliculin gene identified a novel mutation in exon 9 (c.997_998delTC; p.Ser333ArgfsX56). Except for the lung manifestation, no other features of BHD syndrome were detected in this case. Here, we report a case of BHD syndrome that manifested only as lung disease with a novel mutation.
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