Ann Coloproctol.  2014 Oct;30(5):222-227. 10.3393/ac.2014.30.5.222.

Effectiveness of Sodium Picosulfate/Magnesium Citrate (PICO) for Colonoscopy Preparation

• Song KH
• Suh WS
• Jeong JS
• Kim DS
• Kim SW
• Kwak DM
• Hwang JS
• Kim HJ
• Park MW
• Shim MC
• Koo JI
• Kim JH
• Shon DH

• KMID: 2263865
• DOI: http://doi.org/10.3393/ac.2014.30.5.222

Abstract

PURPOSE
Bowel preparation with sodium phosphate was recently prohibited by the U.S. Food and Drug Administration. Polyethylene glycol (PEG) is safe and effective; however, it is difficult to drink. To identify an easy bowel preparation method for colonoscopy, we evaluated three different bowel preparation regimens regarding their efficacy and patient satisfaction.
METHODS
In this randomized, comparative study, 892 patients who visited a secondary referral hospital for a colonoscopy between November 2012 and February 2013 were enrolled. Three regimens were evaluated: three packets of sodium picosulfate/magnesium citrate (PICO, group A), two packets of PICO with 1 L of PEG (PICO + PEG 1 L, group B), and two packets of PICO with 2 L of PEG (PICO + PEG 2 L, group C). A questionnaire survey regarding the patients' preference for the bowel preparation regimen and satisfaction was conducted before the colonoscopies. The quality of bowel cleansing was scored by the colonoscopists who used the Aronchick scoring scale and the Ottawa scale.
RESULTS
The patients' satisfaction rate regarding the regimens were 72% in group A, 64% in group B, and 45.9% in group C. Nausea and abdominal bloating caused by the regimens were more frequent in group C than in group A or group B (P < 0.01). Group C showed the lowest preference rate compared to the other groups (P < 0.01). Group C showed better right colon cleansing efficacy than group A or group B.
CONCLUSION
Group A exhibited a better result than group B or group C in patient satisfaction and preference. In the cleansing quality, no difference was noted between groups A and C.

Keyword

Sodium picosulfate magnesium citrate; Satisfaction; Bowel preparation; Polyethylene glycols; Colonoscopy

MeSH Terms

Citric Acid*
Colon
Colonoscopy*
Humans
Nausea
Patient Satisfaction
Polyethylene Glycols
Secondary Care Centers
Sodium*
United States Food and Drug Administration
Surveys and Questionnaires
Citric Acid
Polyethylene Glycols
Sodium