Korean J Med.
2012 Jul;83(1):132-135.
Renal Insufficiency Secondary to Leukemic Infiltration in Chronic Lymphocytic Leukemia: A Case Report
- Affiliations
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- 1Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea. Dr-Yi@paik.ac.kr
- 2Department of Pathology, Inje University Ilsan Paik Hospital, Goyang, Korea.
- 3Department of Radiology, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea.
Abstract
- Renal infiltration is common in chronic lymphocytic leukemia (CLL), but renal impairment caused by leukemic infiltration is rare. This report describes the case of a 38-year-old man with CLL who required no medical treatment for 1 year and was admitted with nonoliguric renal insufficiency (proteinuria > 2,000 mg/day). A renal biopsy subsequently revealed leukemic infiltration by CLL. Treatment with fludarabine plus cyclophosphamide resulted in the improvement of renal function. Leukemic infiltration should be considered in the differential diagnosis of a patient with CLL and impaired renal function because renal impairment often responds well to chemotherapy.
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